ISCHEMIC HEART DISEASE IN NUCLEAR WORKERS FIRST EMPLOYED AT THE MAYAK PA IN 1948-1972
ISCHEMIC HEART DISEASE IN NUCLEAR WORKERS FIRST EMPLOYED AT THE MAYAK PA IN 1948-1972
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DOI：
10.1097/hp.0b013e3182243a62
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发表时间：
2012-07-01
期刊：
影响因子：
2.2
通讯作者：
O'Hagan, Jacqueline A.
中科院分区：
文献类型：
--
作者：
Azizova, Tamara V.;Muirhead, Colin R.;O'Hagan, Jacqueline A.
继2010年发表的缺血性心脏病（IHD）发病率和死亡率的早期研究之后，基于扩展队列和额外5年的随访进行了第二次分析。该群体包括18 763名工人，其中25%是女性，他们于1948-1972年首次在Mayak PA就业，并一直跟踪到2005年底。其中一些工人仅暴露于外部伽马射线，另一些则暴露于外部伽马射线和内部α粒子辐射的混合物。在研究队列中共确定了6，134例IHD病例和2，629例死亡。调整非辐射因素后，IHD发病率随外照射总剂量的增加而增加（ERR/戈伊0.099; 95%CI：0.045-0.153），差异有统计学意义。当调整内部肝脏剂量时，该值略有降低。在IHD发生率中，内部肝脏剂量无统计学显著增加趋势。这些发现与早期的研究一致。IHD发病率的新发现显示，与外部剂量低于0.2戈伊的工人相比，外部剂量为0.2-0.5戈伊的工人的IHD发病率在统计学上显著降低。这种降低的风险在很大程度上受到女工的影响。这一发现在其他研究中从未报道过，因此应谨慎对待这一结果。IHD死亡率的结果与早期分析中的结果相似;在调整外部剂量后，外部γ射线剂量或内部肝脏剂量无统计学显著趋势。从这些分析中获得的风险估计IHD发病率和死亡率与外部伽马射线的队列的Mayak工人一般是兼容的，从其他大型职业辐射工作者的研究和日本原子弹爆炸幸存者。健康物理学103（1）：3-14; 2012
Following an earlier study of incidence and mortality of ischemic heart disease (IHD) published in 2010, a second analysis has been conducted based on an extended cohort and five additional years of follow-up. The cohort includes 18,763 workers, of whom 25% were females, first employed at the Mayak PA in 1948-1972 and followed up to the end of 2005. Some of these workers were exposed to external gamma rays only, and others were exposed to a mixture of external gamma-rays and internal alpha-particle radiation. A total of 6,134 cases and 2,629 deaths from IHD were identified in the study cohort. A statistically significant increasing trend was found with total external gamma-ray dose in IHD incidence (ERR/Gy 0.099; 95% CI: 0.045-0.153) after adjusting for non-radiation factors. This value reduced slightly when adjusting for internal liver dose. There was no statistically significant increase trend for internal liver dose in IHD incidence. These findings were consistent with an earlier study. New findings in IHD incidence revealed a statistically significant decrease in IHD incidence among workers exposed to external gamma-rays doses of 0.2-0.5 Gy in relation to the external doses below 0.2 Gy. This decreased risk is heavily influenced by female workers. This finding has never been reported in other studies, and the results should be treated with caution. The findings for IHD mortality are similar to those results in the earlier analysis; there was no statistically significant trend with external gamma-ray dose or for internal liver dose after adjustment for external dose. The risk estimates obtained from these analyses of IHD incidence and mortality in relation to external gamma-rays in the cohort of Mayak workers are generally compatible with those from other large occupational radiation worker studies and the Japanese atomic bomb survivors. Health Phys. 103(1):3-14; 2012