Recent Insight into the Role of the PD-1/PD-L1 Pathway in Feto-Maternal Tolerance and Pregnancy
Recent Insight into the Role of the PD-1/PD-L1 Pathway in Feto-Maternal Tolerance and Pregnancy
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PD-1/PD-L1 通路在胎儿-母体耐受性和妊娠中的作用的最新见解
DOI：
10.1111/aji.12365
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发表时间：
2015
影响因子：
3.6
通讯作者：
Liao Ai-Hua
中科院分区：
文献类型：
--
作者：
Zhang Yong-Hong;Tian Mei;Tang Mao-Xing;Liu Zhao-Zhao;Liao Ai-Hua
怀孕对孕妇的免疫系统是一个巨大的挑战。鉴于母体同种异体反应性淋巴细胞在怀孕期间没有耗尽，局部和/或全身机制必须在改变母体免疫反应中起核心作用。调节性T细胞（Tregs）和PD‐1/PD‐L1通路都是控制免疫应答的关键。最近的研究已经证明PD‐1/PD‐L1通路通过促进Tregs的发育和功能，抑制效应T细胞的激活，在调节T细胞稳态和外周耐受性方面具有重要作用。PD‐1/PD‐L1通路在胎母界面和妊娠中的作用已经在人类和动物妊娠模型中进行了研究。在这篇综述中，我们提供了PD‐1/PD‐L1通路在调节T细胞稳态、母体耐受性和妊娠相关并发症中的作用，以及它在临床免疫治疗中的可能适用性。
Pregnancy presents a great challenge to the maternal immune system. Given that maternal alloreactive lymphocytes are not depleted during pregnancy, local and/or systemic mechanisms have to serve a central function in altering the maternal immune responses. Regulatory T cells (Tregs) and the PD‐1/PD‐L1 pathway are both critical in controlling the immune responses. Recent studies have proved the critical function of the PD‐1/PD‐L1 pathway in regulating the T‐cell homeostasis and the peripheral tolerance through promoting the development and function of Tregs, and inhibiting the activation of effector T cells. The function of the PD‐1/PD‐L1 pathway in feto‐maternal interface and pregnancy has been investigated in human and animal models of pregnancy. In this review, we provide recent insight into the role of the PD‐1/PD‐L1 pathway in regulating T‐cell homeostasis, maternal tolerance, and pregnancy‐related complications as well as its possible applicability in clinical immunotherapy.