Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: The relevance of genetic diversity and phylodynamics for vaccine strategies
Reconstructing the epidemic history of HIV-1 circulating recombinant forms CRF07_BC and CRF08_BC in East Asia: The relevance of genetic diversity and phylodynamics for vaccine strategies
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DOI：
10.1016/j.vaccine.2009.07.101
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发表时间：
2010-05-26
期刊：
影响因子：
5.5
通讯作者：
Tee, Kok Keng
中科院分区：
文献类型：
--
作者：
Takebe, Yutaka;Liao, Huanan;Tee, Kok Keng
HIV-1 CRF07_BC和CRF08_BC是在中国具有严重公共卫生后果的密切相关的循环重组形式（CRF）。这些CRI的时间和空间动态的确定，估计他们的分歧的时间，使用系统发育和贝叶斯合并的方法。对CRF07_BC和CRF08_BC的时间轴研究将这些菌株的扩展追溯到它们的起源云南省。本研究强调了将进化和分子流行病学分析纳入对艾滋病毒流行病起源的深入了解的相关性，为确定区域和全球公共卫生政策，包括未来的疫苗战略提供了信息。皇冠版权所有（C）2009由爱思唯尔有限公司出版。保留所有权利。
HIV-1 CRF07_BC and CRF08_BC are closely related circulating recombinant forms (CRFs) with serious public health consequences in China. The temporal and spatial dynamics of these CRI's were determined by estimating their times of divergence, using phylogenetic and Bayesian coalescent methods. Studies of the timelines of CRF07_BC and CRF08_BC trace the expansion of these strains back their origins to Yunnan province. The present study highlights the relevance of incorporating evolutionary and molecular epidemiological analyses into an in-depth understanding of the genesis of HIV epidemic, providing information for determining regional and global public health policies, including future vaccine strategies. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.