Cognitive assessment of a representative community population with Parkinson's disease (PD) using the Cambridge Cognitive Assessment-Revised (CAMCOG-R)
Cognitive assessment of a representative community population with Parkinson's disease (PD) using the Cambridge Cognitive Assessment-Revised (CAMCOG-R)
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DOI：
10.1093/ageing/afi098
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发表时间：
2005-05-01
期刊：
影响因子：
6.7
通讯作者：
Walker, RW
中科院分区：
文献类型：
--
作者：
Athey, RJ;Porter, RW;Walker, RW
背景资料：认知能力下降在帕金森病（PD）中得到了广泛的认可，但用于此类患者的最佳认知评估工具仍不清楚。30分的简易精神状态检查（MMSE）虽然使用起来快速而简单，但未能涵盖所有认知领域，并且被认为具有天花板效应。剑桥认知评估-修订版（CAMCOG-R）是一种认知筛查工具，可以评估许多不同的认知领域。它以前没有被专门用于PD subjects.Methods：一个流行的社区人口的135 PD患者进行了评估认知使用MMSE。MMSE评分25分或以上的患者随后使用CAMCOG-R进行进一步评估。人口统计学和疾病因素，包括疾病的持续时间，症状的严重程度，焦虑，抑郁和幻觉的存在被recorded.Results：31/135（23%）表现出认知功能障碍的MMSE（得分25）。<其余94例患者（10例被排除）的中位总CAMCOG-R评分为89/104。结果被广泛传播。受试者在定向、理解和感知等认知领域的得分特别高，但在记忆和抽象思维方面相对较低。随着年龄的增长，PD症状严重程度的增加和疾病持续时间的增加，在整个认知领域的评分显着降低（P 0.05），但不存在焦虑，抑郁或幻觉的subjects.Discussion：CAMCOG-R被认为是一个可行的和有用的认知筛查工具，用于PD。<在先前通过MMSE评估为没有显著认知障碍的受试者中证明了广泛的认知能力。该小组在某些认知领域的表现比其他人更差，那些年龄较大，PD症状更严重，症状持续时间更长的人得分较低。
Background: cognitive decline is well recognised in Parkinson's disease (PD) but the best cognitive assessment tool for use in such patients remains unclear. The 30-point Mini-Mental State Examination (MMSE), while quick and straightforward to use, fails to cover a full range of cognitive domains and is recognised to have a ceiling effect. The Cambridge Cognitive Assessment-Revised (CAMCOG-R) is a cognitive screening tool allowing the assessment of a number of different domains of cognition. It has not previously been used specifically on PD subjects.Methods: a prevalent community population of 135 PD patients were assessed cognitively using the MMSE. Those scoring 25 or above on the MMSE were subsequently further assessed using CAMCOG-R. Demographic and disease factors including disease duration, symptom severity, anxiety, depression and the presence of hallucinations were recorded for each participant.Results: 31/135 (23%) demonstrated cognitive impairment on the MMSE (score < 25). Ninety-four of the remaining group (10 were excluded) achieved a median total CAMCOG-R score of 89/104. The results were widely distributed. The subjects scored particularly highly in the cognitive domains of orientation, comprehension and perception but relatively poorly at memory and abstract thinking. Significantly poorer scores (P< 0.05) were seen throughout the cognitive domains with increasing age, increasing PD symptom severity and increasing disease duration, but not with the presence of anxiety, depression or hallucinations in the subjects.Discussion: CAMCOG-R was found to be a viable and useful cognitive screening tool for use in PD. A wide range of cognitive ability was demonstrated in subjects who had been assessed previously by the MMSE as not having significant cognitive impairment. The group performed worse in certain cognitive domains than others and those who were older, with more severe PD symptoms and with symptoms for longer, scored less well.