Dermatological and immunological conditions due to nerve lesions
Dermatological and immunological conditions due to nerve lesions
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DOI：
10.11138/fneur/2013.28.2.083
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发表时间：
2013-04-01
影响因子：
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通讯作者：
Ruocco, Eleonora
中科院分区：
文献类型：
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作者：
Bove, Domenico;Lupoli, Amalia;Ruocco, Eleonora
神经科医生和皮肤科医生都对某些综合征感兴趣，因为皮肤受累可能是神经系统疾病的先兆症状。本次审查的目的是澄清这一方面。皮肤因其与周围感觉神经系统、自主神经系统和中枢神经系统的关系而构成神经免疫内分泌器官。皮肤含有许多从感觉神经释放的神经肽。神经肽在皮肤生理学和病理生理学以及某些皮肤疾病中发挥着精确的作用。神经肽的复杂失调是皮肤病学和神经病学感兴趣的一些疾病的一个特征（例如带状疱疹感染后的皮肤和神经病变、腕管综合征的皮肤表现、三叉神经营养综合征）。皮肤科医生需要知道何时应将患者转诊至神经科医生，并且对于那些出现病因不明的综合征的患者应考虑这种选择。
Some syndromes are of interest to both neurologists and dermatologists, because cutaneous involvement may harbinger symptoms of a neurological disease. The aim of this review is to clarify this aspect. The skin, because of its relationships with the peripheral sensory nervous system, autonomic nervous system and central nervous system, constitutes a neuroim-munoendocrine organ. The skin contains numerous neuropeptides released from sensory nerves. Neuropeptides play a precise role in cutaneous physiology and pathophysiology, and in certain skin diseases. A complex dysregulation of neuropeptides is a feature of some diseases of both dermatological and neurological interest (e.g. cutaneous and nerve lesions following herpes zoster infection, cutaneous manifestations of carpal tunnel syndrome, trigeminal trophic syndrome).Dermatologists need to know when a patient should be referred to a neurologist and should consider this option in those presenting with syndromes of unclear etiology.