Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women
Adipose tissue oxygenation is associated with insulin sensitivity independently of adiposity in obese men and women
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DOI：
10.1111/dom.13329
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发表时间：
2018-09-01
影响因子：
5.8
通讯作者：
Blaak, Ellen E.
中科院分区：
文献类型：
--
作者：
Goossens, Gijs H.;Vogel, Max A. A.;Blaak, Ellen E.
脂肪组织（AT）功能障碍有助于胰岛素抵抗和2型糖尿病的病理生理学。以前的研究表明，改变AT氧合影响脂肪细胞的功能，但它仍然有待阐明是否改变AT氧合更密切相关的肥胖或胰岛素敏感性。在本研究中，我们检验了AT氧合与胰岛素敏感性相关而不是与人类肥胖相关的假设。35名葡萄糖代谢正常或受损的瘦型和肥胖型个体（21名男性和14名女性，年龄40-65岁）参加了一项横断面单中心研究。我们测量腹部皮下AT氧合，身体成分和胰岛素敏感性。在男性和女性中，与年龄、体重指数和体脂百分比相似的肥胖胰岛素敏感（IS）个体相比，肥胖胰岛素抵抗者的AT氧合更高。肥胖IS和瘦IS男性之间AT氧合无显著差异。此外，AT氧合与胰岛素抵抗呈正相关（r = 0.465; P = 0.005），即使在调整年龄，性别和体脂百分比后（标准化= 0.479; P = 0.005）。总之，腹部皮下AT氧合与男性和女性的胰岛素敏感性相关，与肥胖无关。因此，AT氧合可能是改善胰岛素敏感性的有希望的靶点。
Adipose tissue (AT) dysfunction contributes to the pathophysiology of insulin resistance and type 2 diabetes. Previous studies have shown that altered AT oxygenation affects adipocyte functionality, but it remains to be elucidated whether altered AT oxygenation is more strongly related to obesity or insulin sensitivity. In the present study, we tested the hypothesis that AT oxygenation is associated with insulin sensitivity rather than adiposity in humans. Thirty-five lean and obese individuals (21 men and 14 women, aged 40-65 years) with either normal or impaired glucose metabolism participated in a cross-sectional single-centre study. We measured abdominal subcutaneous AT oxygenation, body composition and insulin sensitivity. AT oxygenation was higher in obese insulin resistant as compared to obese insulin sensitive (IS) individuals with similar age, body mass index and body fat percentage, both in men and women. No significant differences in AT oxygenation were found between obese IS and lean IS men. Moreover, AT oxygenation was positively associated with insulin resistance (r = 0.465; P = .005), even after adjustment for age, sex and body fat percentage (standardized = 0.479; P = .005). In conclusion, abdominal subcutaneous AT oxygenation is associated with insulin sensitivity both in men and women, independently of adiposity. AT oxygenation may therefore be a promising target to improve insulin sensitivity.