T helper subsets in allergic eye disease.
T helper subsets in allergic eye disease.
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DOI：
10.1097/aci.0000000000000088
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发表时间：
2014-10
影响因子：
2.8
通讯作者：
Saban DR
中科院分区：
文献类型：
--
作者：
Reyes NJ;Saban DR
Ocular allergy is an IgE-mediated disease that results in inflammation of the conjunctiva and, in more severe cases, the cornea. This is driven by an immediate hypersensitivity response via mast cells, followed by a late phase response mediated by eosinophils—both of which are indeed dependent on T helper (Th) lymphocyte activity. Here we provide an update on Th subsets (Th1, Th2, Th17, T regulatory (Treg) and their relevance in ocular allergy. Recent evidence in ocular allergy points to an involvement of other Th subsets, in addition to Th2. However, how these subsets are respectively activated and their role in mediating the different clinical forms is poorly understood. Novel mouse models may facilitate addressing such unknowns, and future challenges will involve how to translate such findings into more effective and “patho-specific” treatments. Ocular allergy, especially in severe forms, involves subsets other than Th2. Th1 cells have been detected in mild and severe forms, and recent evidence points to a possible role for IL-17 in severe disease. Tregs, on the other hand, dampen pathogenic Th cell function and allergy immunotherapy is associated with Treg augmentation in disease management. Further understanding of Th biology is warranted and may lead to better therapies.
