Interleukin-6 Blood Levels in Sensitive and Multiresistant Tuberculosis
Interleukin-6 Blood Levels in Sensitive and Multiresistant Tuberculosis
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DOI：
10.1007/s15010-008-7398-3
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发表时间：
2009-04-01
期刊：
影响因子：
7.5
通讯作者：
Cavadas, B.
中科院分区：
文献类型：
--
作者：
Correia, J. W.;Freitas, M. V.;Cavadas, B.
白细胞介素6(IL-6)是一种促炎细胞因子，与结核病的免疫发病机制有关。结核病的多药耐药性在世界范围内被认为是一个重要的公共卫生问题。结核病发病机制，尤其是耐药机制还不是很清楚，但IL-6可能是增强耐药结核病病理的一个因素。本研究对38例活动性肺结核患者的血IL-6水平进行检测，其中23例对特异性化疗(STB)非常敏感，15例(MDRTB)对多药耐药(MDRTB)。采用双抗体夹心法对38例结核病患者和63例健康献血员血清中IL-6进行定量，其中STB组男16例(73.9%)，女7例；MDRTB组9例(60%)，女6例；对照组51例(81%)，女12例。结果显示，肺结核患者血清IL-6浓度(中位数为4.3pg/ml，范围为0.001-24)明显高于健康人(中位数为0.5pg/ml，范围为0-2.8pg/ml，P<0.05)。此外，与对照组(P<；0.001)相比，STB组(中位数=4.1pg/ml，范围0.5-24)和MDRTB组(中位数=5.1pg/ml，范围0.5-12)的IL-6浓度均升高。相比之下，STB组和MDRTB组之间没有显著差异(p>；0.05)。肺结核患者IL-6水平升高，与耐药性无关。
Interleukin-6 (IL-6) is a proinflammatory cytokine implicated in the immunopathogenesis of tuberculosis (TB). Multidrug resistance in tuberculosis is recognized worldwide as an important public health issue. The mechanism underlying TB pathogenesis in general and drug resistance in particular is not well understood, but it may be that IL-6 is one factor that enhances pathology in drug-resistant TB. The purpose of this study was to identify patterns of IL-6 production in active pulmonary TB with different sensitivity to standard drug therapy.IL-6 blood levels were studied in 38 patients with active pulmonary TB: 23 patients were very sensitive to specific chemotherapy (STB), and 15 were multiresistant (MDRTB). An ELISA assay (Biossource) was used to quantify IL-6 in the sera of 38 TB patients and 63 healthy blood donors.The STB group was composed of 16 males (73.9%) and 7 females, MDRTB by 9 males (60%) and 6 females, and control group by 51 males (81%) and 12 females. The results showed a significant increase in IL-6 concentration in TB (median = 4.3 pg/ml, range 0.5-24) compared to that of healthy individuals (median = 0.5 pg/ml, range 0-2.8, p < 0.001). Additionally, IL-6 concentrations were increased in both STB (median = 4.1 pg/ml, range 0.5-24) and MDRTB (median = 5.1 pg/ml, range 0.5-12) groups in relation to controls (p < 0.001). In contrast, significant differences were not observed between STB and MDRTB groups (p > 0.05).IL-6 levels were increased in pulmonary tuberculosis, independent of drug resistance.