Toward effective immunotherapy for the treatment of malignant brain tumors.
Toward effective immunotherapy for the treatment of malignant brain tumors.
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DOI：
10.1016/j.nurt.2009.04.003
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发表时间：
2009-07
期刊：
影响因子：
--
通讯作者：
Sampson JH
中科院分区：
文献类型：
--
作者：
Mitchell DA;Sampson JH
长期以来，癌症的免疫治疗一直被认为是一种靶向分子治疗方法，有望在对周围正常组织造成最小损害的情况下根除肿瘤细胞。然而，对于大多数人类癌症来说，免疫治疗在调节癌症进展方面的有效性仍然缺乏一个证明性的例子。最近我们对导致t细胞完全激活的机制的理解取得了突破，并认识到克服肿瘤诱导的免疫抑制机制的重要性，这为如何在人类中产生有效的抗肿瘤免疫反应提供了新的思路，并激发了新的热情，以实现癌症免疫治疗的全部潜力。侵袭性恶性脑肿瘤的免疫治疗也没有逃脱这种重新焕发活力的努力，并且有希望的治疗方法目前正在全球几家机构的数十个临床试验中积极研究。这篇综述将集中在我们对如何产生有效的抗肿瘤免疫反应的理解方面的一些最重要的突破，以及在为大多数恶性脑肿瘤患者实现有效免疫治疗方面面临的一些明确的挑战。本文综述了目前正在进行临床评估的免疫治疗策略，并概述了一些有前景的新方法，以期为恶性脑肿瘤的有效免疫治疗提供积极和坚定的进展。
The immunologic treatment of cancer has long been heralded as a targeted molecular therapeutic with the promise of eradicating tumor cells with minimal damage to surrounding normal tissues. However, a demonstrative example of the efficacy of immunotherapy in modulating cancer progression is still lacking for most human cancers. Recent breakthroughs in our understanding of the mechanisms leading to full T-cell activation, and recognition of the importance of overcoming tumor-induced immunosuppressive mechanisms, have shed new light on how to generate effective anti-tumor immune responses in humans, and sparked a renewed and enthusiastic effort to realize the full potential of cancer immunotherapy. The immunologic treatment of invasive malignant brain tumors has not escaped this reinvigorated endeavor, and promising therapies are currently under active investigation in dozens of clinical trials at several institutions worldwide. This review will focus on some of the most important breakthroughs in our understanding of how to generate potent anti-tumor immune responses, and some of the clear challenges that lie ahead in achieving effective immunotherapy for the majority of patients with malignant brain tumors. A review of immunotherapeutic strategies currently under clinical evaluation, as well as an outline of promising novel approaches on the horizon, is included in order to provide perspective on the active and stalwart progress toward effective immunotherapy for the treatment of malignant brain tumors.
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DOI：
10.1084/jem.193.11.1303
发表时间：
2001-06-04
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Dieckmann D;Plottner H;Berchtold S;Berger T;Schuler G
通讯作者：
Schuler G
影响因子：
11.2
作者：
Chen, Aoshuang;Liu, Shanrong;Zheng, Guoxing
通讯作者：
Zheng, Guoxing
影响因子：
11.2
作者：
Fecci, PE;Mitchell, DA;Sampson, JH
通讯作者：
Sampson, JH
影响因子：
45.3
作者：
Dudley, ME;Wunderlich, JR;Rosenberg, SA
通讯作者：
Rosenberg, SA
影响因子：
15.9
作者：
Caruso, DA;Orme, LM;Ashley, DA
通讯作者：
Ashley, DA