Configuration of bioreactors.

Configuration of bioreactors.
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生物反应器的配置。

DOI:
10.1007/978-1-62703-733-4_19
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发表时间:
2014
影响因子:
--
通讯作者:
M. Streefland
M. Streefland
中科院分区:
--
文献类型:
--
作者:
D. Martens;E. J. van den End;M. Streefland

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实验室规模的搅拌式生物反应器(L 0.2-20)用于动物细胞的基础研究和大规模生产的工艺开发和故障排除。在本章中,简要讨论了生物反应器系统的不同配置,并描述了这些不同配置的设置。此外,还介绍了生物反应器参数的在线测量和控制,特别是控制器设置(PID)和氧气消耗和二氧化碳产生的在线测量。最后介绍了氧传递系数的测定方法。
Lab-scale stirred-tank bioreactors (0.2-20 l) are used for fundamental research on animal cells and in process development and troubleshooting for large-scale production. In this chapter, different configurations of bioreactor systems are shortly discussed and setting up these different configurations is described. In addition, online measurement and control of bioreactor parameters is described, with special attention to controller settings (PID) and online measurement of oxygen consumption and carbon dioxide production. Finally, methods for determining the oxygen transfer coefficient are described.
DOI: 10.1016/j.jbiotec.2003.09.007
发表时间: 2004-01-08
影响因子: 4.1
作者:
Korke, R;Gatti, MD;Hu, WS
通讯作者: Hu, WS