Tablet Content Analysis Using Terahertz Transmission Spectroscopy
Tablet Content Analysis Using Terahertz Transmission Spectroscopy
复制标题
使用太赫兹透射光谱分析片剂含量
DOI：
10.1007/s12247-007-9002-2
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发表时间：
2007
影响因子：
2.6
通讯作者：
T. Lo
中科院分区：
文献类型：
--
作者：
J. Spencer;E. Jefferson;A. Hussain;D. Newnham;T. Lo
将对乙酰氨基酚含量在60 ~ 120 mg之间的压片以透射模式在2 cm−1 ~ 120 cm−1的太赫兹光谱区进行扫描。采用高效液相色谱法测定对乙酰氨基酚片的含量。尽管缺乏可识别的光谱特征，并且片剂在45 cm−1以上是不透明的，但可以构建一个工作的偏最小二乘模型。结果表明，吸光度与片剂成分在太赫兹范围内呈预期的线性关系。不同压片力对太赫兹光谱没有明显影响。
A group of pressed tablets with acetaminophen content between 60 mg and 120 mg were scanned in the terahertz spectral region (2 cm−1–120 cm−1) in transmission mode. Tablet acetaminophen content was determined by a standard HPLC method. Despite the lack of discernible spectral features and the tablets being opaque above 45 cm−1, a working partial least squares model could be constructed. The results show the expected linearity between absorbance and tablet composition in the terahertz range. There were no observable effects on the terahertz spectra due to different tablet compaction force.