Role of Notch signaling in regulating innate immunity and inflammation in health and disease.
Role of Notch signaling in regulating innate immunity and inflammation in health and disease.
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DOI：
10.1007/s13238-016-0250-0
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发表时间：
2016-03
期刊：
影响因子：
21.1
通讯作者：
Hu X
中科院分区：
文献类型：
--
作者：
Shang Y;Smith S;Hu X
Notch信号通路从果蝇到哺乳动物都是保守的，并且在发育过程中起关键作用。在免疫系统中，已经确定Notch信号传导调节中枢和外周淋巴器官中T和B细胞发育的多个步骤。相对于Notch信号传导在淋巴细胞发育中的充分记录的作用，对其在调节髓系发育和功能中的作用知之甚少，特别是在急性和慢性炎症的背景下。在这篇综述文章中，我们将描述近年来积累的证据来支持Notch通路在先天免疫和炎症反应中的关键调节作用，并讨论这种调节对炎症性疾病的发病机制和治疗的潜在影响。
The Notch signaling pathway is conserved from Drosophila to mammals and is critically involved in developmental processes. In the immune system, it has been established that Notch signaling regulates multiple steps of T and B cell development in both central and peripheral lymphoid organs. Relative to the well documented role of Notch signaling in lymphocyte development, less is known about its role in regulating myeloid lineage development and function, especially in the context of acute and chronic inflammation. In this review article, we will describe the evidence accumulated during the recent years to support a key regulatory role of the Notch pathway in innate immune and inflammatory responses and discuss the potential implications of such regulation for pathogenesis and therapy of inflammatory disorders.