Guest-responsive supramolecular hydrogels expressing selective sol-gel transition for sulfated glycosaminoglycans
Guest-responsive supramolecular hydrogels expressing selective sol-gel transition for sulfated glycosaminoglycans
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DOI：
10.1038/s41428-020-0341-x
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发表时间：
2020-04-23
期刊：
影响因子：
2.8
通讯作者：
Tamaru, Shun-ichi
中科院分区：
文献类型：
--
作者：
Kuroda, Naofumi;Tounoue, Yukie;Tamaru, Shun-ichi
含有Phe-Lys二肽的Bola型pi-共轭两亲分子发生了pH和客体诱导的从颗粒聚集体到纤维结构的相变，形成了超分子水凝胶。利用这种刺激响应性，该水凝胶体系成功地应用于由一个硫酸基糖单元组成的糖胺多聚糖的选择性识别。本文描述了由两个含有苯丙氨酸的二肽组成的Bola型两亲性水凝胶构建的刺激响应性水凝胶。N-端氨基酸残基是一种两亲性的苯丙氨酸-赖氨酸序列，在有限的pH条件下形成水凝胶，影响了两亲分子的水凝胶形成能力。凝胶的形成是由于凝胶剂组件在受pH控制的过程中从粒状聚集体到纤维结构的相变。这种刺激响应的溶胶-凝胶转变也是通过添加阴离子聚合物来完成的，并利用该水凝胶系统成功地识别了硫酸氨基聚糖。
A bola-type pi-conjugated amphiphile containing Phe-Lys dipeptide showed a pH- and guest-induced phase transition from the granular aggregate to the fibrous architecture and formed a supramolecular hydrogel. Using this stimuli-responsiveness, the hydrogel system was successfully applied to the selective discrimination of glycosaminoglycans composed of a sulfated sugar unit.This paper describes the stimuli-responsive hydrogels constructed from bola-type amphiphiles composed of two dipeptides containing phenylalanine attached to the ends of a hydrophobic tetrathiophene. The hydrogel formation ability of the amphiphiles was affected by the N-terminal amino acid residue, which is an amphiphile-possessing phenylalanine-lysine sequence that formed a hydrogel under limited pH conditions. Gel formation occurred because of the phase transition of the gelator assembly from a granular aggregate to a fibrous architecture, in a process controlled by pH. This stimuli-responsive sol-gel transition was also accomplished by the addition of an anionic polymer, and sulfated glycosaminoglycans were successfully discriminated using the hydrogel system.