Strain Dependent Variation of Immune Responses to A. fumigatus: Definition of Pathogenic Species
Strain Dependent Variation of Immune Responses to A. fumigatus: Definition of Pathogenic Species
复制标题
烟曲霉免疫反应的菌株依赖性变异：病原菌种的定义
作者：
L. Rizzetto;Gloria Giovannini;M. Bromley;P. Bowyer;L. Romani;D. Cavalieri
世纪以来，微生物学家和免疫学家将微生物分类为致病性或非致病性种或属。这一定义在大多数细菌的菌株和种属水平上明显相关，其中特定种属菌株之间的毒力差异是众所周知的，但从未在真菌种属的菌株水平上进行过探讨。在这里，我们测试了免疫反应性和致病潜力的收集菌株曲霉属，真菌，通常被认为是致病性的免疫功能低下的主机。我们的研究结果表明，广泛的应变依赖性的变化引起的免疫反应表明，不同的分离株具有不同的毒力和感染性。因此，炎症或致病性标志物的定义不能一概而论。对不同免疫反应的分子机制的深刻理解将仅来自于对具有极其不同特性的菌株的比较研究。
For over a century microbiologists and immunologist have categorized microorganisms as pathogenic or non-pathogenic species or genera. This definition, clearly relevant at the strain and species level for most bacteria, where differences in virulence between strains of a particular species are well known, has never been probed at the strain level in fungal species. Here, we tested the immune reactivity and the pathogenic potential of a collection of strains from Aspergillus spp, a fungus that is generally considered pathogenic in immuno-compromised hosts. Our results show a wide strain-dependent variation of the immune response elicited indicating that different isolates possess diverse virulence and infectivity. Thus, the definition of markers of inflammation or pathogenicity cannot be generalized. The profound understanding of the molecular mechanisms subtending the different immune responses will result solely from the comparative study of strains with extremely diverse properties.
影响因子：
64.8
作者：
Aimanianda, Vishukumar;Bayry, Jagadeesh;Latge, Jean-Paul
通讯作者：
Latge, Jean-Paul
影响因子：
11.8
作者：
Upton, Arlo;Kirby, Katharine A.;Marr, Kieren A.
通讯作者：
Marr, Kieren A.