Amygdala gray matter concentration is associated with extraversion and neuroticism
Amygdala gray matter concentration is associated with extraversion and neuroticism
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DOI：
10.1097/01.wnr.0000186596.64458.76
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发表时间：
2005-11-28
期刊：
影响因子：
1.7
通讯作者：
Canli, T
中科院分区：
文献类型：
--
作者：
Omura, K;Constable, RT;Canli, T
本研究采用高分辨率磁共振成像和基于体素的形态测量法对41名健康个体进行了研究，一方面评估了外向性和神经质的人格特质与局部脑容量和灰质浓度的个体差异之间的关联，另一方面，特别关注了annygdala。外向性与左侧杏仁核的灰质浓度呈正相关，而神经质与右侧杏仁核的灰质浓度呈负相关。考虑到神经质是抑郁症的一个危险因素，我们的发现提供了一个解释，为什么以前对抑郁症患者的结构成像研究（没有控制人格）产生了相互矛盾的结果。此外，我们的数据与以下观点一致：在抑郁症患者中观察到的annygdala减少是在疾病发作之前，而不是疾病的后果。
Using high-resolution magnetic resonance imaging and voxel-based morphometry in 41 healthy individuals, this study evaluated the association between the personality traits of extraversion and neuroticism, on the one hand, and individual differences in localized brain volume and gray matter concentration, on the other, with a special focus on the annygdala. Extraversion was positively correlated with gray matter concentration in the left amygdala, whereas neuroticism was negatively correlated with gray matter concentration in the right amygdala. Given that neuroticism is a risk factor for depression, our finding offers one explanation as to why prior structural imaging studies of depressed patients (which did not control for personality) produced conflicting findings. Furthermore, our data are consistent with the view that annygdala reduction seen in depressed patients precedes the onset of the disease, rather than being a consequence of the illness.