Nicotine Levels in Electronic Cigarettes
Nicotine Levels in Electronic Cigarettes
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DOI：
10.1093/ntr/nts103
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发表时间：
2013-01-01
影响因子：
4.7
通讯作者：
Kosmider, Leon
中科院分区：
文献类型：
--
作者：
Goniewicz, Maciej L.;Kuma, Tomasz;Kosmider, Leon
电子香烟（EC）是一种模仿传统香烟的塑料装置，旨在以无毒蒸汽的形式输送尼古丁。当人通过该装置吹气时，溶液中的尼古丁被加热并蒸发，并以蒸汽形式吸入口中。EC是市场上的一种新产品，对其安全性和尼古丁输送功效知之甚少。该研究的目的是分析各种EC品牌和型号产生的蒸汽中的尼古丁水平。本研究旨在评估各种EC将尼古丁转化为蒸汽的有效性和一致性，并分析尼古丁蒸发的动力学。和美国市场。蒸汽产生使用自动吸烟机修改，以模拟真实的EC用户的膨化条件。尼古丁被吸收在一套洗涤瓶与甲醇和气相色谱分析。尼古丁的总水平产生的蒸汽20系列的15喷烟从0.5到15.4毫克不等。大多数分析的EC在前150-180次抽吸期间有效地递送尼古丁。平均而言，50%-60%的尼古丁从烟弹中蒸发。EC产生含有尼古丁的蒸汽，但EC品牌和型号在尼古丁蒸发的功效和一致性方面有所不同。在有效蒸发尼古丁的EC中，15口吸入的量与吸传统香烟相比要低。
The electronic cigarette (EC) is a plastic device that imitates conventional cigarettes and was developed to deliver nicotine in a toxin-free vapor. Nicotine in a solution is heated and vaporized when a person puffs through the device and is inhaled as a vapor into the mouth. The EC is a new product on the market and little is known about its safety and nicotine delivery efficacy. The aim of the study was to analyze nicotine levels in vapor generated from various EC brands and models. The study was designed to assess efficacy and consistency of various ECs in converting nicotine to vapor and to analyze dynamics of nicotine vaporization.Sixteen ECs were selected based on their popularity in the Polish, U.K. and U.S. markets. Vapors were generated using an automatic smoking machine modified to simulate puffing conditions of real EC users. Nicotine was absorbed in a set of washing bottles with methanol and analyzed with gas chromatography.The total level of nicotine in vapor generated by 20 series of 15 puffs varied from 0.5 to 15.4 mg. Most of the analyzed ECs effectively delivered nicotine during the first 150-180 puffs. On an average, 50%-60% of nicotine from a cartridge was vaporized.ECs generate vapor that contains nicotine, but EC brands and models differ in their efficacy and consistency of nicotine vaporization. In ECs, which vaporize nicotine effectively, the amount inhaled from 15 puffs is lower compared with smoking a conventional cigarette.