The reaction of aromatic α,β‐unsaturated ketones with 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones
The reaction of aromatic α,β‐unsaturated ketones with 4,5‐diamino‐1,6‐dihydropyrimidin‐6‐ones
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DOI：
10.1002/jhet.5570310111
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发表时间：
1994
影响因子：
2.4
通讯作者：
B. Insuasty;Monica Ramos;J. Quiroga;Adolfo Sánchez;M. Nogueras;Norbert Hanold;H. Meier
中科院分区：
文献类型：
--
作者：
B. Insuasty;Monica Ramos;J. Quiroga;Adolfo Sánchez;M. Nogueras;Norbert Hanold;H. Meier
4，5-二氨基-1，6-二氢嘧啶-6-酮1与一个相当于查尔酮2的化合物在酸性介质中反应生成2，4-diaryl-2，3，6，7-tetrahydro-1H-pyrimido[4，5-b][1，4]diazepin-6-ones 3a-m。产物的结构鉴定是基于详细的核磁共振研究，包括选择性的13C[1H]去偶联实验。
The reaction of 4,5-diamino-1,6-dihydropyrimidin-6-ones 1 with one equivalent of the chalcones 2 leads in an acidic medium to the formation of the 2,4-diaryl-2,3,6,7-tetrahydro-1H-pyrimido[4,5-b][1,4]diazepin-6-ones 3a-m. The structure elucidation of the products is based on detailed nmr investigations including selective 13C[1H] decoupling experiments.