Modeling Ischemia in the Immature Brain: How Translational Are Animal Models?
Modeling Ischemia in the Immature Brain: How Translational Are Animal Models?
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DOI：
10.1161/strokeaha.115.007776
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发表时间：
2015-10
期刊：
影响因子：
8.3
通讯作者：
Vexler ZS
中科院分区：
文献类型：
--
作者：
Mallard C;Vexler ZS
共振光谱法）和CBF，与在患有HIE的人类婴儿中观察到的相似。14.一般而言，损伤的特征是感觉运动皮层和基底神经节的神经元损失和产后癫痫发作。新生猪HI模型，13与胎羊研究平行，10已被用于开发治疗HIE足月儿的低温。在兔中，在妊娠22天内诱导子宫内缺血，相当于早产，并在妊娠结束时（29天）模拟足月损伤。早产兔HI主要损害皮质下区，如基底节和丘脑。15重要的是，早产兔HI模型是少数几种大型动物设置之一，其已经证明了新生幼崽中磁共振成像异常、神经病理学和脑瘫样高渗运动缺陷之间的相关性。15
resonance spectroscopy) and CBF similar to that observed in human infants with HIE. 14 In general, injury is characterized by neuronal loss in the sensorimotor cortex and basal ganglia and postnatal seizures. The HI models in newborn pigs, 13 in parallel with fetal sheep studies, 10 have been instrumental in development of therapeutic hypothermia for term infants with HIE.In rabbits, intrauterine ischemia is induced≈ 22 days of gestation as equivalent to the preterm, and at the end of gestation (at 29 days) to mimic at-term injury. HI in preterm rabbits results in injury mainly in subcortical areas, such as basal ganglia and thalamus. 15 Importantly, the preterm rabbit HI model is one of few large animal set-ups, which has demonstrated a correlation between abnormalities on magnetic resonance imaging, neuropathology, and cerebral palsy-like hypertonic motor deficits in the newborn pups. 15