Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.
Making Novel Genetic Associations With Carotid Intima-Media Thickness Using the UK Biobank.
复制标题
利用英国生物库建立颈动脉内膜中层厚度的新遗传关联。
DOI：
10.1161/atvbaha.119.313784
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发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Finn,AlokeV
中科院分区：
文献类型：
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作者：
Guo,Liang;Cornelissen,Anne;Sakamoto,Atsushi;Finn,AlokeV
颈动脉内膜中层厚度（cIMT）可以通过超声测量进行无创评估，并已被广泛用作亚临床动脉粥样硬化的替代品和心血管事件的预测因子。1到目前为止，仅进行了几项使用cIMT表型的大型全基因组关联研究。2，3在最新一期的ATVB中，Strawbridge等人4介绍了迄今为止来自英国生物银行的最大规模的单一研究，该研究在2006年至2010年期间在英国招募了50万名年龄在40至69岁之间的人。根据22179例患者的一致cIMT测量数据，作者确定了4个与平均cIMT相关的新位点，并验证了先前报道的11个位点中的7个，其中2个先前与缺血性心脏病相关。4与平均cIMT和颈动脉斑块相关的新的和已知的基因座总结见表。
Carotid artery intima-media thickness (cIMT) can be noninvasively assessed by ultrasound measurement and has been widely used as a surrogate for subclinical atherosclerosis and predictor of cardiovascular events. 1 So far, only a few large genome-wide association studies using cIMT phenotyping have been conducted. 2, 3 In the current issue of ATVB, Strawbridge et al4 present the largest single study to date originating from the UK Biobank, which recruited 500 000 people aged 40 to 69 years between 2006 and 2010 across the United Kingdom. With data from consistent cIMT measurements in 22 179 patients available, the authors identified 4 novel loci associated with mean cIMT and validated 7 of 11 previously reported loci with 2 of them previously associated with ischemic heart disease. 4 A summary of the new and known loci associated with mean cIMT and carotid plaque is given in the Table.