Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches
Breakdown in epithelial barrier function in patients with asthma: Identification of novel therapeutic approaches
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DOI：
10.1016/j.jaci.2009.05.037
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发表时间：
2009-07-01
影响因子：
14.2
通讯作者：
Davies, Donna E.
中科院分区：
文献类型：
--
作者：
Swindle, Emily J.;Collins, Jane E.;Davies, Donna E.
支气管上皮在提供吸入环境的化学、物理和免疫屏障方面起关键作用。这些屏障有助于维持正常的体内平衡，但当受到破坏时，免疫屏障就会被激活，以保护肺的内部环境。我们讨论了目前对哮喘患者这些屏障功能异常的理解，并考虑了针对这一关键结构的新治疗机会。[J] .过敏症临床免疫杂志2009；24:23-34。
The bronchial epithelium is pivotally involved in the provision of chemical, physical, and immunologic barriers to the inhaled environment. These barriers serve to maintain normal homeostasis, but when compromised, the immunologic barrier becomes activated to protect the internal milieu of the lung. We discuss what is currently understood about abnormalities in these barrier functions in patients with asthma and consider novel therapeutic opportunities that target this key structure. (J Allergy Clin Immunol 2009;124:23-34.)