Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions
Initial clinical results for breath-hold CT-based processing of respiratory-gated PET acquisitions
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DOI：
10.1007/s00259-008-0858-2
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发表时间：
2008-11-01
影响因子：
9.1
通讯作者：
Meyer, Marc-Etienne
中科院分区：
文献类型：
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作者：
Fin, Loic;Daouk, Joeel;Meyer, Marc-Etienne
目的呼吸运动引起胸部结构正电子发射断层扫描(PET)图像的摄取扩散并与CT图像错误配准。这种配准错误可能会改变衰减校正，从而改变PET图像的量化。在这篇文章中，我们介绍了基于单次屏气CT(BH-CT)采集的呼吸门控PET(RG-PET)处理方法的第一个临床结果，该方法寻求通过更好的PET-CT联合配准来提高诊断准确性。我们将这种方法称为基于CT的RG-PET处理。患者接受了标准的临床PET方案，然后是基于CT的方案，其中包括10分钟列表模式RG-PET采集，然后是浅末呼气BH-CT。通过比较CT和CT图像上病变质心的距离来评价基于CT和临床的PET方法各自的性能。结果基于CT的方法与临床方法相比，质心距显著降低(p=0.027)，平均变化量为-49%；范围为-100%~0%。这导致了更高的SUVmax(平均变化=+33%；范围=-4%至69%)。基于CT的正电子发射计算机断层扫描的病灶体积(平均变化量为-39%，范围为-74%~-1%)明显低于临床体积(p=0.022)。结论基于CT的正电子发射计算机断层扫描图像处理方法可以在放射剂量增加不大的情况下应用于临床。它改善了PET-CT对肺部病变的联合配准，并应导致更准确的衰减校正，从而进行SUV测量。
Purpose Respiratory motion causes uptake in positron emission tomography (PET) images of chest structures to spread out and misregister with the CT images. This misregistration can alter the attenuation correction and thus the quantisation of PET images. In this paper, we present the first clinical results for a respiratory-gated PET (RG-PET) processing method based on a single breath-hold CT (BH-CT) acquisition, which seeks to improve diagnostic accuracy via better PET-to-CT co-registration. We refer to this method as "CT-based" RG-PET processing.Methods Thirteen lesions were studied. Patients underwent a standard clinical PET protocol and then the CT-based protocol, which consists of a 10-min List Mode RG-PET acquisition, followed by a shallow end-expiration BH-CT. The respective performances of the CT-based and clinical PET methods were evaluated by comparing the distances between the lesions' centroids on PET and CT images. SUVMAX and volume variations were also investigated.Results The CT-based method showed significantly lower (p = 0.027) centroid distances (mean change relative to the clinical method=-49%; range=-100% to 0%). This led to higher SUVMAX (mean change=+33%; range=-4% to 69%). Lesion volumes were significantly lower (p=0.022) in CT-based PET volumes (mean change=-39%: range=-74% to -1%) compared with clinical ones.Conclusions A CT-based RG-PET processing method can be implemented in clinical practice with a small increase in radiation exposure. It improves PET-CT co-registration of lung lesions and should lead to more accurate attenuation correction and thus SUV measurement.