Oriented Collagen Scaffolds for Tissue Engineering.
Oriented Collagen Scaffolds for Tissue Engineering.
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DOI：
10.3390/ma5030501
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发表时间：
2012-03-16
期刊：
影响因子：
--
通讯作者：
Kodama S
中科院分区：
文献类型：
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作者：
Isobe Y;Kosaka T;Kuwahara G;Mikami H;Saku T;Kodama S
通过排列流动取向的胶原线凝胶，并对排列的凝胶进行脱水，制备了片状、网状和管状的定向胶原支架。开发的胶原支架可以是任何实际尺寸和任何方向的组织工程应用。用平行Nicols法对胶原支架的双折射进行了定量分析。由于人体内的天然胶原具有骨、软骨、肌腱和角膜等取向，而这种取向对人体器官的功能具有特殊的作用，因此开发的各种三维取向的胶原支架有望成为组织工程和再生医学的有用生物材料。
Oriented collagen scaffolds were developed in the form of sheet, mesh and tube by arraying flow-oriented collagen string gels and dehydrating the arrayed gels. The developed collagen scaffolds can be any practical size with any direction of orientation for tissue engineering applications. The birefringence of the collagen scaffolds was quantitatively analyzed by parallel Nicols method. Since native collagen in the human body has orientations such as bone, cartilage, tendon and cornea, and the orientation has a special role for the function of human organs, the developed various types of three-dimensional oriented collagen scaffolds are expected to be useful biomaterials for tissue engineering and regenerative medicines.