Predictors of Weight Loss During Radiotherapy in Patients With Stage I or II Head and Neck Cancer
Predictors of Weight Loss During Radiotherapy in Patients With Stage I or II Head and Neck Cancer
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DOI：
10.1002/cncr.25041
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发表时间：
2010-05-01
期刊：
影响因子：
6.2
通讯作者：
Meyer, Francois
中科院分区：
文献类型：
--
作者：
Nourissat, Alice;Bairati, Isabelle;Meyer, Francois
贝克：该研究的目的是确定I期或II期头颈部（HN）癌患者放疗（RT）期间体重减轻的预测因素。方法：本研究作为3期化学预防试验的一部分进行。共有540例患者接受了随机化。患者在RT前后称重。他们的基线特征，包括生活习惯、饮食和生活质量，被评估为潜在的预测因素。使用多元线性回归确定预测因子。用Bootstrap检验模型的可靠性。生成受试者操作特征曲线以估计模型在预测临界重量损失（>= 5%）方面的准确性。结果：平均体重减轻2.2 kg（标准差3.4）。五个因素与体重减轻相关：除了声门喉以外的所有HN癌部位（P
BAKCGROUND: The purpose of the study was to identify predictors of weight loss during radiotherapy (RT) in patients with stage I or II head and neck (HN) cancer. METHODS: This study was conducted as part of a phase 3 chemoprevention trial. A total of 540 patients were randomized. The patients were weighed before and after RT. Their baseline characteristics, including lifestyle habits, diet, and quality of life, were assessed as potential predictors. Predictors were identified using multiple linear regressions. The reliability of the model was assessed by bootstrap resampling. A receiver operating characteristics curve was generated to estimate the model's accuracy in predicting critical weight loss (>= 5%). RESULTS: The mean weight loss was 2.2 kg (standard deviation, 3.4). Five factors were associated with a greater weight loss: all HN cancer sites other than the glottic larynx (P