Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults
Sex differences in the association between amyloid and longitudinal brain volume change in cognitively normal older adults
复制标题
DOI：
10.1016/j.nicl.2019.101769
复制
发表时间：
2019-01-01
影响因子：
4.2
通讯作者：
Resnick, Susan M.
中科院分区：
文献类型：
--
作者：
Armstrong, Nicole M.;Huang, Chiung-Wei;Resnick, Susan M.
目的：淀粉样蛋白阳性是AD病理学的生物标志物，但淀粉样蛋白阳性与脑体积变化（尤其是海马）之间的相关性并不一致。我们假设，在认知正常的老年人中，关联的性别差异可能导致不一致的发现。使用线性混合效应模型，我们研究了淀粉样蛋白阳性与预期体积变化的关系。（平均= 3.3次访问）海马旁回（phg），海马，内嗅皮层（erc），楔前叶，在171名年龄≥ 55岁的巴尔的摩老龄化纵向研究参与者中，淀粉样蛋白阳性定义为平均C-11-匹兹堡化合物B（Pi B）分布体积比（DVR）临界值为1.062。所有分析包括年龄、种族、性别、教育、APOE e4携带状态以及这些协变量与时间的双向相互作用。增加了性别和PiB +/-状态之间的双向相互作用以及性别和PiB +/-状态与时间的三向相互作用，以评估性别是否改变了相关性。PiB+状态与phg中更大的体积下降相关（β =-0.036，SE = 0.011，p = 0.001）和erc（β =-0.019，SE = 0.009，p = 0.045）。性别改变了PiB+状态与梭形肌体积下降率的相关性（β =-0.117，SE = 0.049，p = 0.019）。PiB+男性的phg体积下降速率更陡（β =-0.051，SE = 0.013，p <0.001）和erc（β =-0.029，SE = 0.012，p = 0.014），而PiB+和PiB-女性之间的体积变化率没有差异。淀粉样变性是内嗅和海马旁体积丢失的标志。在男性中，淀粉样蛋白阳性是受早期AD病理影响的脑区域体积损失的预测因子，但不是女性。
Objective: Amyloid positivity is a biomarker of AD pathology, yet the associations between amyloid positivity and brain volumetric changes, especially in the hippocampus, are inconsistent. We hypothesize that sex differences in associations may contribute to inconsistent findings among cognitively normal older adults.Methods: Using linear mixed effects models, we examined the association of amyloid positivity with prospective volumetric changes (mean = 3.3 visits) of parahippocampal gyrus (phg), hippocampus, entorhinal cortex (erc), precuneus, and fusiform gyrus among 171 Baltimore Longitudinal Study of Aging participants aged >= 55 years. Amyloid positivity was defined by a mean C-11-Pittsburgh Compound B (PiB) distribution volume ratio (DVR) cut-off of 1.062. All analyses included age, race, sex, education, APOE e4 carrier status, and two-way interactions of these covariates with time. Two-way interaction between sex and PiB+/- status and three-way interaction of sex and PiB+/- status with time were added to assess whether sex modified associations.Results: PiB+ status was associated with greater volumetric declines in the phg (beta = -0.036, SE = 0.011, p = 0.001) and erc (beta = -0.019, SE = 0.009, p = 0.045). Sex modified the association of PiB+ status and rates of volumetric declines in fusiform (beta = -0.117, SE = 0.049, p = 0.019). PiB+ males had steeper rates of volumetric declines in phg (beta = -0.051, SE = 0.013, p < 0.001) and erc (beta = -0.029, SE = 0.012, p = 0.014) than PiB- males, while there was no difference in rates of volumetric change between PiB+ and PiB- females.Conclusions: Amyloidosis is a marker of entorhinal and parahippocampal volume loss. Amyloid positivity is a predictor of volume loss in brain regions affected by early AD pathology in men, but not women.