Human Papillomavirus and Cervical Cancer in Australasia and Oceania: Risk-factors, Epidemiology and Prevention
Human Papillomavirus and Cervical Cancer in Australasia and Oceania: Risk-factors, Epidemiology and Prevention
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DOI：
10.1016/j.vaccine.2008.05.041
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发表时间：
2008-08-19
期刊：
影响因子：
5.5
通讯作者：
Jones, Ronald W.
中科院分区：
文献类型：
--
作者：
Garland, Suzanne M.;Brotherton, Julia M. L.;Jones, Ronald W.
包括澳大利亚、新西兰、斐济和巴布亚新几内亚在内的澳大拉西亚和大洋洲区域在种族、文化和行为方面是一个多样化的区域。与世界其他地方一样，人乳头瘤病毒（HPV）-16和18是最常见的高风险类型，在25岁以下的妇女中发病率最高。这两种高危型HPV最常见于宫颈癌和高度发育不良，尽管大洋洲许多国家的数据很少。2007年4月，澳大利亚成为世界上第一个开始政府资助的通用HPV疫苗计划的国家。以学校为基础的方案以12岁的女性为目标，正在进行中，一个追赶方案将于2009年年中完成，目标是26岁。疫苗接种工作已经全面展开，在该倡议实施的第一年，约有75%的在校女生接受了完整的疫苗接种计划。这为其他国家提供了一个成功的模式。我们提供了有关宫颈癌、危险因素和预防策略的数据，包括HPV的流行病学和HPV疫苗策略。皇冠版权所有（c）2008由爱思唯尔有限公司出版。保留所有权利。
The region encompassing Australasia and Oceania, including Australia, New Zealand, Fiji and Papua New Guinea, is a diverse one with respect to ethnicities, cultures and behaviours, It includes countries with comprehensive cervical cytology screening programmes which can be credited with significant reductions in cervical cancer incidence and mortality, and countries with no prevention programmes and significantly higher incidence and mortality. As elsewhere in the world, human papillomavirus (HPV)-16 and 18 are the commonest high-risk types, with the highest rates in women under 25 years of age. These two high-risk HPV types are found most frequently in cervical cancers and high-grade dysplasias, although there are minimal data for many countries in Oceania. In April 2007, Australia became the first country worldwide to commence a government funded universal HPV vaccine programme. The school-based programme targets 12-year old females in an ongoing schedule, with a catch-up programme up to 26 years of age, to be completed in mid-2009. Vaccine introduction has been comprehensively rolled out, with around 75% uptake of the complete vaccine schedule among school-girls in the first year of this initiative. This represents a successful model for other countries. We present data on cervical cancer, risk factors and prevention strategies, including epidemiology of HPV and HPV vaccine strategies. Crown Copyright (c) 2008 Published by Elsevier Ltd. All rights reserved.