CHARACTERIZATION OF THE ANTIBODY-RESPONSE IN MICE WITH TYPE-II COLLAGEN-INDUCED ARTHRITIS, USING MONOCLONAL ANTI-TYPE II COLLAGEN ANTIBODIES
CHARACTERIZATION OF THE ANTIBODY-RESPONSE IN MICE WITH TYPE-II COLLAGEN-INDUCED ARTHRITIS, USING MONOCLONAL ANTI-TYPE II COLLAGEN ANTIBODIES
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DOI：
10.1002/art.1780290314
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发表时间：
1986-03-01
影响因子：
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通讯作者：
WIGZELL, H
中科院分区：
文献类型：
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作者：
HOLMDAHL, R;RUBIN, K;WIGZELL, H
对20种与II型胶原反应的单克隆抗体就其决定簇特异性以及与软骨来源成分的反应性进行了鉴定。这些单克隆抗体与天然II型胶原三螺旋结构上的7种不同表位发生反应。识别其中3种表位的抗体在患关节炎小鼠的血清中比在无关节炎小鼠的血清中更频繁出现。体内注射一些选定的自身反应性抗体可导致滑膜炎，但在任何情况下都不会引发全面性关节炎。
Twnety monoclonal antibodies reactive with type II collagen were characterized as to their determinant specificity and their reactivity with cartilage-derived components. The monoclonal antibodies reacted with 7 different epitopes on the native type II collagen triple helical structure. Antibodies defining 3 of these epitopes occurred more frequently in sera from arthritic mice than in sera from nonarthritic mice. In vivo injection of some selected autoreactive antibodies caused synovitis, but in no case did it give rise to full-blown arthritis.