Impact of type 2 diabetes mellitus on recurrent myocardial infarction in China
Impact of type 2 diabetes mellitus on recurrent myocardial infarction in China
复制标题
中国2型糖尿病对复发性心肌梗死的影响
DOI：
10.1177/1479164116653606
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发表时间：
2016-11-01
影响因子：
2.4
通讯作者：
Jin, Qiangsong
中科院分区：
文献类型：
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作者：
Li, Wentao;Li, Muwei;Jin, Qiangsong
为了评估2型糖尿病对中国既往心肌梗死患者长期预后的影响，我们研究了864例既往心肌梗死患者，其中251例合并2型糖尿病，613例无2型糖尿病，中位随访时间为2.9年。2型糖尿病患者分为胰岛素治疗组95例和非胰岛素治疗组156例。2型糖尿病患者与非2型糖尿病患者复发性心肌梗死的粗发生率（每1000患者年）为43.7 vs 25.1，全因死亡为68.7 vs 28.3，复合终点（即复发性心肌梗死或全因死亡）为99.8 vs 49.9。Cox回归分析显示，复发性心肌梗死、全因死亡及其合并的校正风险比分别为1.67（95%可信区间：1.06-2.74）、1.90（1.25-2.90）和1.72（1.23-2.40）。胰岛素治疗与全因死亡之间也存在显著关联。我们的研究结果提示，2型糖尿病是既往心肌梗死患者复发性心肌梗死、全因死亡和复合终点的独立危险因素。
To evaluate the influence of type 2 diabetes mellitus on the long-term outcomes of Chinese patients with previous myocardial infarction, we studied 864 patients with previous myocardial infarction, including 251 with type 2 diabetes mellitus and 613 without type 2 diabetes mellitus, over a median follow-up time of 2.9 years. The type 2 diabetes mellitus patients were subdivided into 95 insulin-treated diabetes mellitus and 156 non-insulin-treated diabetes mellitus subjects. The crude incidences (per 1000 patient-years) in the type 2 diabetes mellitus subjects versus the non-type 2 diabetes mellitus subjects were 43.7 versus 25.1 for recurrent myocardial infarction, 68.7 versus 28.3 for all-cause death and 99.8 versus 49.9 for the composite end point (i.e. recurrent myocardial infarction or all-cause death). Cox regression analysis showed that the adjusted hazard ratios for recurrent myocardial infarction, all-cause death and their combination were 1.67 (95% confidence interval: 1.06–2.74), 1.90 (1.25–2.90) and 1.72 (1.23–2.40), respectively. Significant associations were also observed between insulin treatment and all-cause death. Our findings suggested that type 2 diabetes mellitus is an independent risk factor for recurrent myocardial infarction, all-cause death and the composite end point among previous myocardial infarction patients.