Conceptual barriers to understanding physical barriers.
Conceptual barriers to understanding physical barriers.
复制标题
DOI：
10.1016/j.semcdb.2015.04.008
复制
发表时间：
2015-06
影响因子：
7.3
通讯作者：
Turner JR
中科院分区：
文献类型：
--
作者：
Lingaraju A;Long TM;Wang Y;Austin JR 2nd;Turner JR
Claudin蛋白大家族的成员调节穿过紧密连接的离子和水通量。许多Claudins，例如Claudins 2和15，通过形成大小和电荷选择性的细胞旁通道来实现这一点。Claudins似乎对紧密连接链的形成和其他蛋白质的募集到这些位置也是必不可少的。不太清楚的是，克劳迪斯是否也形成了细胞旁密封。虽然当Claudins被破坏时，这种密封是有缺陷的，但包括超微结构和生化数据在内的一些结果表明，脂结构是紧密连接链的重要组成部分，可能是细胞旁密封的原因。本文重点介绍了Claudins对屏障功能和紧密连接结构的研究现状，并提出了Claudins和其他紧密连接蛋白可以驱动脂质基链结构的组装和稳定的模型。
The members of the large family of claudin proteins regulate ion and water flux across the tight junction. Many claudins, e.g. claudins 2 and 15, accomplish this by forming size- and charge-selective paracellular channels. Claudins also appear to be essential for genesis of tight junction strands and recruitment of other proteins to these sites. What is less clear is whether claudins also form the paracellular seal. While this seal is defective when claudins are disrupted, some results, including ultrastructural and biochemical data, suggest that lipid structures are an important component of tight junction strands and may be responsible for the paracellular seal. This review highlights the current knowledge of claudins to barrier function and tight junction structure and suggests a model by which claudins and other tight junction proteins can drive assembly and stabilization of a lipid-based strand structure.