Innervation of the carotid body: Immunohistochemical, denervation, and retrograde tracing studies
Innervation of the carotid body: Immunohistochemical, denervation, and retrograde tracing studies
复制标题
DOI：
10.1002/jemt.10193
复制
发表时间：
2002-11-01
影响因子：
2.5
通讯作者：
Ichikawa, H
中科院分区：
文献类型：
--
作者：
Ichikawa, H
本文综述了颈动脉体中多种神经化学物质的研究进展。血管周围的神经纤维和化学感受器内的球细胞含有酪氨酸羟化酶（TH）、降钙素基因相关肽（CGRP）、P物质（SP）、甘丙肽（GAL）、血管活性肠肽（VIP）、神经肽Y（NPY）、钙视网膜蛋白（CR）、钙结合蛋白D-28 k（CB）、小清蛋白（PV）和一氧化氮合酶（NOS）的免疫反应性（IR）。分布于颈动脉体周围的副交感神经元含有VIP、胆碱乙酰转移酶和香草酸受体1样受体。在哺乳动物颈动脉体中，颈动脉窦神经（CSN）的横断导致CGRP-，SP-和NOS-免疫反应（IR）神经纤维的缺失或减少，而所有的NPY-IR神经纤维消失后去除的上级颈神经节。交感神经节切除后，大部分VIP-IR神经纤维消失，但少数仍存在。此外，CSN横断似乎导致大鼠颈动脉体内最初免疫阴性的球细胞和神经纤维中GAL-IR的获得。另一方面，4%，25%，17%，和不到1%的岩神经元逆行标记的CSN含有TH-，CGRP-，SP-和VIP-IR，分别。在鸡颈动脉体，许多CGRP和SP-IR神经纤维消失后迷走神经切断或结状神经节切除。切除交感干第14颈神经节后，GAL-、NPY-和VIP-IR神经纤维大多消失。各种神经化学物质存在于颈动脉体的起源和功能意义进行了讨论。(C)2002 Wiley-Liss，Inc.
This review presents information about multiple neurochemical substances in the carotid body. Nerve fibers around blood vessels and glomus cells within the chemoreceptive organ contain immunoreactivities (IR) for tyrosine hydroxylase (TH), calcitonin gene-related peptide (CGRP), substance P (SP), galanin (GAL), vasoactive intestinal polypeptide (VIP), neuropeptide Y (NPY), calretinin (CR), calbindin D-28k (CB), parvalbumin (PV), and nitric oxide synthase (NOS). Parasympathetic neurons scattered around the carotid body contain VIP, choline acetyltransferase, and vanilloid receptor 1-like receptor. In the mammalian carotid body, transection of the carotid sinus nerve (CSN) causes the absence or decrease of CGRP-, SP-, and NOS-immunoreactive (IR) nerve fibers, whereas all NPY-IR nerve fibers disappear after removal of the superior cervical ganglion. Most VIP-IR nerve fibers disappear but a few persist after sympathetic ganglionectomy. In addition, the CSN transection appears to cause the acquisition of GAL-IR in originally immunonegative glomus cells and nerve fibers within the rat carotid body. On the other hand, 4%, 25%, 17%, and less than 1% of petrosal neurons retrogradely labeled from the rat CSN contain TH-, CGRP-, SP-, and VIP-IR, respectively. In the chicken carotid body, many CGRP- and SP-IR nerve fibers disappear after vagus nerve transection or nodose ganglionectomy. GAL-, NPY-, and VIP-IR nerve fibers mostly disappear after removal of the 14th cervical ganglion of the sympathetic trunk. The origin and functional significance of the various neurochemical substances present in the carotid body is discussed. (C) 2002 Wiley-Liss, Inc.