THE MULTIFACETED ROLE OF T CELL-MEDIATED IMMUNITY IN PATHOGENESIS AND RESISTANCE TO MYCOPLASMA RESPIRATORY DISEASE.
THE MULTIFACETED ROLE OF T CELL-MEDIATED IMMUNITY IN PATHOGENESIS AND RESISTANCE TO MYCOPLASMA RESPIRATORY DISEASE.
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发表时间：
2009
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通讯作者：
N. Dobbs;A. Odeh;Xiangle Sun;J. Simecka
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作者：
N. Dobbs;A. Odeh;Xiangle Sun;J. Simecka
支原体呼吸道疾病对经济、健康和野生动物有重大影响。这些疾病的标志是支原体感染和与气道相关的慢性炎症反应的持续存在。关于支原体疾病的免疫机制和对感染的抵抗力还有很多需要了解。很明显，免疫应答可以促进支原体呼吸道疾病中炎性病变的产生，以及提供保护以免受微生物的感染和肺外传播。这种肺部疾病的演变是在先天免疫机制和不同T细胞群的对比效应的控制下。支原体疾病涉及的免疫机制是多方面的，其复杂性的迷人故事正在被揭开。支原体呼吸道疾病的研究强调了这样一种观点，即呼吸道对感染因子的免疫沿着是一个动态过程，涉及细胞和细胞因子信号网络，其决定所产生的反应类型，并最终决定感染的结果。本文的目的是概述我们在支原体疾病和免疫方面的工作，重点是影响疾病发病机制的T细胞反应的相互作用和调节。我们将首先概述参与控制感染和参与产生T细胞应答的免疫机制，并讨论T细胞群在产生保护和促进病变发展中的作用。
Mycoplasma respiratory diseases have a significant impact on the economy, health and wildlife. The hallmark of these diseases is the persistence of the mycoplasma infections and chronic inflammatory responses associated with the airways. There is still much that needs to be understood about the immune mechanisms involved in mycoplasma disease and resistance from infection. It is clear that immune responses can contribute to the generation of inflammatory lesions in mycoplasma respiratory disease, as well as provide protection from infection and extrapulmonary dissemination of the organisms. The evolution of this lung disease is under the control innate immune mechanisms and the contrasting effects of different T cell populations. The mechanisms of immunity involved in mycoplasma diseases are multifaceted, and a fascinating story of its complexity is being uncovered. Research in mycoplasma respiratory diseases have underscored the idea that immunity along the respiratory tract against infectious agents is a dynamic process and involves a network of cellular and cytokine signals that determine the type of responses generated, and ultimately, the outcome of infection. The aim of this article is to present on overview of our work on mycoplasma disease and immunity, focusing on the interactions and regulation of T cell responses that influence disease pathogenesis. We will first provide an overview of immune mechanisms involved in controlling infection and participate in the generation of T cell responses, and the role of T cell populations in generating protection and contributing to lesion development will be discussed.