Inorganic phosphate as a signaling molecule in osteoblast differentiation
Inorganic phosphate as a signaling molecule in osteoblast differentiation
复制标题
DOI：
10.1002/jcb.10622
复制
发表时间：
2003-10-01
影响因子：
4
通讯作者：
Beck, GR
中科院分区：
文献类型：
--
作者：
Beck, GR
成骨细胞形成矿化基质所需的许多事件的空间和时间协调仅部分了解。这一过程的复杂性和最终产物的性质要求这些细胞具有仔细监测细胞外环境中事件的机制，并具有通过细胞和分子变化做出反应的能力。在分化过程中无机磷酸盐的产生可能是一个这样的信号。除了需要无机磷酸盐作为羟基磷灰石矿物Ca-10（PO 4）（6）（OH）（2）的成分外，许多研究还表明，在矿化之前的事件中也需要无机磷酸盐。然而，对比的结果，生理相关性，以及缺乏一个明确的机制（S）已经产生了一些争论的意义，磷酸盐升高的分化过程。最近，一些研究已经开始阐明细胞内无机磷酸盐升高可能的细胞和分子后果。这些结果表明，在成骨细胞分化过程中产生的无机磷酸盐本身可能代表一种信号，能够促进矿化所需的多种因子的表达和调节的时间协调。成骨细胞分化过程中无机磷酸盐升高对蛋白质功能和基因表达的调节可能是矿化细胞监测和响应细胞外环境变化的一种机制。2003年出版Wiley-Liss，Inc.
The spatial and temporal coordination of the many events required for osteogenic cells to create a mineralized matrix are only partially understood. The complexity of this process, and the nature of the final product, demand that these cells have mechanisms to carefully monitor events in the extracellular environment and have the ability to respond through cellular and molecular changes. The generation of inorganic phosphate during the process of differentiation may be one such signal. In addition to the requirement of inorganic phosphate as a component of hydroxyapatite mineral, Ca-10(PO4)(6)(OH)(2), a number of studies have also suggested it is required in the events preceding mineralization. However, contrasting results, physiological relevance, and the lack of a clear mechanism(s) have created some debate as to the significance of elevated phosphate in the differentiation process. More recently, a number of studies have begun to shed light on possible cellular and molecular consequences of elevated intracellular inorganic phosphate. These results suggest a model in which the generation of inorganic phosphate during osteoblast differentiation may in and of itself represent a signal capable of facilitating the temporal coordination of expression and regulation of multiple factors necessary for mineralization. The regulation of protein function and gene expression by elevated inorganic phosphate during osteoblast differentiation may represent a mechanism by which mineralizing cells monitor and respond to the changing extracellular environment. Published 2003 Wiley-Liss, Inc.