High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia
High intake of energy, sucrose, and polyunsaturated fatty acids is associated with increased risk of preeclampsia
复制标题
DOI：
10.1067/mob.2001.116687
复制
发表时间：
2001-08-01
影响因子：
9.8
通讯作者：
Henriksen, T
中科院分区：
文献类型：
--
作者：
Clausen, T;Slott, M;Henriksen, T
目的：先兆子痫与高体重指数、胰岛素抵抗和高甘油三酯血症有关。我们的目的是前瞻性地调查是否饮食在怀孕的前半期与先兆子痫的风险。研究设计：这一前瞻性，人口为基础的，队列研究的孕妇调查饮食摄入量早在第二个三个月的定量食物频率questionnaire.RESULTS：问卷完成了3133名妇女（83%）。85名妇女出现先兆子痫。能量摄入> 3350 kcal/d与小于或等于2000 kcal/d相比，先兆子痫的校正比值比（95%CI）为3.7（1.5-8.9）。糖摄入量（占总能量的百分比）> 25%与小于或等于8.5%相比，先兆子痫的校正优势比（95% CI）为3.6（1.3-9.8），多不饱和脂肪酸摄入量（占总能量的百分比）>7.5%与小于或等于5.2%相比，先兆子痫的校正优势比（95% CI）为2.6（1.3-5.4）。其他提供能量的营养素与先兆子痫的风险无关。结论：目前的研究表明，高摄入量的能量，蔗糖和多不饱和脂肪酸独立增加先兆子痫的风险。
OBJECTIVE: Preeclampsia is associated with high body mass index, insulin resistance, and hypertriglyceridemia. Our objective was to investigate prospectively whether diet in the first half of pregnancy is associated with the risk for preeclampsia.STUDY DESIGN: This prospective, population-based, cohort study of pregnant women investigated dietary intake early in the second trimester with a quantitative food frequency questionnaire.RESULTS: The questionnaire was completed by 3133 women (83%). Preeclampsia developed in 85 women. Adjusted odds ratio (95% Cl) for preeclampsia was 3.7 (1.5-8.9) for energy intake of > 3350 kcal/d compared with less than or equal to 2000 kcal/d. Adjusted odds ratio (95% Cl) for preeclampsia was 3.6 (1.3-9.8) for sucrose intake (percent of total energy) of > 25% compared with less than or equal to8.5% and 2.6 (1.3-5.4) for polyunsaturated fatty acids intake (percent of total energy) of >7.5% compared with less than or equal to5.2%. Other energy-providing nutrients were not associated with the risk for preeclampsia.CONCLUSION: The current study suggests that high intakes of energy, sucrose, and polyunsaturated fatty acids independently increase the risk for preeclampsia.