Total serum lactate dehydrogenase activity in acute Plasmodium falciparum malaria infection.
Total serum lactate dehydrogenase activity in acute Plasmodium falciparum malaria infection.
复制标题
急性恶性疟原虫疟疾感染中的总血清乳酸脱氢酶活性。
作者：
I. Garba;G. Ubom
介绍
本文测定了18-40岁年龄组急性无并发症恶性疟原虫感染的成年男性76例、女性76例和80例健康成人血清乳酸脱氢酶（LDH）活性。
方法
患者选择和资格预审是通过对在Bauchi专科医院门诊部就诊的个体进行简单随机抽样进行的，这些个体在1至8天内有发热和不适病史，并且通过Giemsa染色薄血玻片的显微镜检查证实感染了恶性疟原虫疟原虫。
结果
男性患者的平均血清LDH活性为789.4 +/- 35.0 IU。该活性显著高于对照LDH活性247.10 +/- 19.0 IU（p值小于0.05）。女性患者的平均血清LDH活性为634.0 +/- 35.0 IU，与对照LDH活性247.10 +/- 19.0 IU相比，相对较高（p值小于0.05）。
结论
合并急性肝细胞损伤和红细胞溶血引起的入侵裂殖子可能占血清LDH活性增加，在这种感染。因此，血清LDH活性是急性无并发症恶性疟原虫疟疾感染的潜在有价值的酶标志物，特别是在没有已知与上述正常血清LDH活性相关的其他并发症的情况下。
INTRODUCTION
Lactate dehydrogenase (LDH) activity was assayed in the sera of 76 adult male and 76 adult female patients within the age group of 18-40 years presenting with acute, uncomplicated Plasmodium falciparum malaria infection and a control group of 80 healthy adults within the same age group.
METHODS
Patient selection and pre-qualification were done by simple random sampling of individuals presenting at the Bauchi Specialist Hospital Outpatient Department with a history of fever and malaise within a period of one to eight days, and who were confirmed to be infected with the P. falciparum malaria parasite by microscopical examination of Giemsa-stained thin blood slides.
RESULTS
The mean serum LDH activity in male patients was found to be 789.4 +/- 35.0 IU. This activity is significantly higher than the control LDH activity of 247.10 +/- 19.0 IU (p-value is less than 0.05). The mean serum LDH activity among female patients was 634.0 +/- 35.0 IU, which is a relatively higher activity compared to the control LDH activity of 247.10 +/- 19.0 IU (p-value is less than 0.05).
CONCLUSION
The combination of acute hepatocellular injury and red cell haemolysis induced by the invading merozoites may account for the increase in serum LDH activity during this infection. Therefore serum LDH activity is a potentially valuable enzymatic marker of acute, uncomplicated P. falciparum malaria infection, especially in the absence of other complicating diseases known to be associated with the above normal serum LDH activities.