Direct High-Resolution Imaging of Crystalline Components in Pharmaceutical Dosage Forms Using Low-Frequency Raman Spectroscopy
Direct High-Resolution Imaging of Crystalline Components in Pharmaceutical Dosage Forms Using Low-Frequency Raman Spectroscopy
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DOI：
10.1021/acs.oprd.5b00329
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发表时间：
2015-11-01
影响因子：
3.4
通讯作者：
Fukami, Toshiro
中科院分区：
文献类型：
--
作者：
Hisada, Hiroshi;Inoue, Motoki;Fukami, Toshiro
有效药物成分的晶体形态需要制药行业清楚地了解和表征，以确保生产正确的剂量。在本研究中，我们使用配备测量模块的拉曼显微镜系统评估了两种不同的药物共晶和咖啡因和4-羟基苯甲酸的物理混合物的晶体形态，以进入低频区域。我们还展示了在药物剂型中共晶的低频拉曼光谱图像与其物理混合物之间的区别：测量的药物剂型是制备的药物共晶，物理混合物和微晶纤维素。在拉曼光谱的低频区可以很容易地分辨出共晶和物理混合物的光谱模式。基于共晶和物理混合物的光谱，用拉曼显微镜观察了药物剂型中两种不同的结晶形式。我们得出结论。该低频拉曼光谱能够直接可视化活性药物的晶体形式，药物剂型中的成分无需任何预处理。
Crystalline forms of active pharmaceutical ingredients need to be clearly understood and characterized by the pharmaceutical industry to ensure the Correct dosage is produced in this study, we evaluated the crystalline form of two different pharmaceutical cocrystals and a physical, mixture consisting, of caffeine and 4-hydroxybenzoic acid using a Raman microscopy system equipped with a measurement module to access the low frequency region. We also demonstrated the difference between a low-frequency Raman spectroscopy image of a cocrystal and its physical mixtute in a pharmaceutical dosage form: The measured pharmaceutical dosage forms were a prepared pharmaceutical cocrystal, a physical mixture, and microcrystalline cellulose. The spectral patterns of the cocrystal and physical mixture were easily distinguished in the low-frequency region of the Raman spectrum. Based on the spectrum of the cocrystal and, physical mixture, two different crystalline forms in the pharmaceutical dosage form were visualized, using, Raman microscopy. We concluded. That low-frequency Raman spectroscopy is able to directly visualize the crystalline form of active pharmaceutical, ingredients in pharmaceutical dosage forms without any pretreatment.