Regional atrophy of the corpus callosum in dementia
Regional atrophy of the corpus callosum in dementia
复制标题
DOI：
10.1017/s1355617708080533
复制
发表时间：
2008-05-01
影响因子：
2.6
通讯作者：
Breitner, John C. S.
中科院分区：
文献类型：
--
作者：
Hallam, Bradley J.;Brown, Warren S.;Breitner, John C. S.
痴呆症患者胼胝体（CC）变性的区域分布尚不清楚。本研究比较了来自Cache县记忆与衰老研究的参与者（n = 179）的区域CC大小。参与者代表了一系列认知功能：阿尔茨海默病（AD）。血管性痴呆（VaD）。轻度模糊认知问题。但还不足以诊断出老年痴呆症和健康问题。从中矢状位磁共振图像中获得的CC轮廓被划分为99个等间距的宽度。这些胼胝体宽度的因子分析确定了10个胼胝体区域。多变量方差分析显示胼胝体前部和后部的组间差异显著。与对照组相比，患者组CC区域的事后两两比较（控制年龄）显示出前、后区域变小的趋势，但没有统计学意义。与对照组相比，AD组的前、后CC区域明显缩小；VaD组的前CC区域明显缩小；MA组的CC区域无明显差异。研究结果表明，痴呆相关的CC萎缩主要发生在前部和后部。
The regional distribution of degeneration of the corpus callosum (CC) in dementia is not yet clear. This Study compared regional CC size in participants (n = 179) from the Cache County Memory and Aging Study. Participants represented a range of cognitive function: Alzheimer's disease (AD). vascular dementia (VaD). mild ambiguous (MA-cognitive problems. but not severe enough for diagnosis of dementia), and health), older adults. CC Outlines obtained from midsagittal magnetic resonance images were divided into 99 equally spaced widths. Factor analysis of these callosal widths identified 10 callosal regions. Multivariate analysis of variance revealed significant group differences for anterior and posterior callosal regions. Post-hoc pairwise comparisons of CC regions in patient groups as compared to the control group (controlling for age) revealed trends toward smaller anterior and posterior re-ions, but riot all were statistically significant. As compared to controls, significantly smaller anterior and posterior CC regions were found in the AD group: significantly smaller anterior CC regions in the VaD group: but no significant CC regional differences in the MA group. Findings suggest that dementia-related CC atrophy occurs primarily in the anterior and posterior portions.