EFFECT OF ZINC SUPPLEMENTATION ON PLASMA HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND ZINC
EFFECT OF ZINC SUPPLEMENTATION ON PLASMA HIGH-DENSITY LIPOPROTEIN CHOLESTEROL AND ZINC
复制标题
DOI：
10.1093/ajcn/35.5.988
复制
发表时间：
1982-01-01
影响因子：
7.1
通讯作者：
YOUNG, R
中科院分区：
文献类型：
--
作者：
FREELANDGRAVES, JH;FRIEDMAN, BJ;YOUNG, R
对32名妇女进行了为期8周的四种水平的锌补充剂（0，15，50或100 mg/天）[以确定锌是否是致动脉粥样硬化剂]。空腹血浆HDL[高密度脂蛋白]-胆固醇和锌每两周测量一次。补充组血浆锌增加，在第4周达到峰值，然后下降到初始值。无论是否继续给予锌，血浆锌的下降可能反映了稳态反应。除100 mg组在第4周时观察到一过性降低-8.4%（57 - 48 mg/dl，P < 0.04）外，其余8周内HDL-胆固醇均无显著差异。显然，在女性中，HDL-胆固醇的降低对所用锌的药理剂量的反应是短暂的，与剂量无关。
Four levels of Zn supplements (0, 15, 50 or 100 mg/day) were given to 32 women for 8 wk [to determine whether Zn is an atherogenic agent]. Fasting plasma HDL[high density lipoprotein]-cholesterol and Zn were measured at biweekly intervals. Plasma Zn increased in the supplemented groups, peaked at wk 4, then decreased toward initial values. The decline in plasma Zn regardless of continuing Zn administration may reflect a homeostatic response. No significant differences were seen in HDL-cholesterol over the 8 wk except in the 100 mg group at wk 4 when a transient decrease, -8.4% (57 to 48 mg/dl, P < 0.04) was observed. Evidently in women the reduction in HDL-cholesterol in response to the pharmacological doses of Zn used was transient and not dose-related.