Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics.
Nucleotide Reverse Transcriptase Inhibitors: A Thorough Review, Present Status and Future Perspective as HIV Therapeutics.
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DOI：
10.2174/1570162x15666171120110145
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发表时间：
2017
影响因子：
1
通讯作者：
Destache CJ
中科院分区：
文献类型：
--
作者：
Holec AD;Mandal S;Prathipati PK;Destache CJ
人类免疫缺陷病毒1型（HIV-1）感染导致获得性免疫缺陷综合征（AIDS），这是一种严重的病毒感染，在2010-2014年期间，美国约有658,507人死亡。抗逆转录病毒（ARV）疗法已被证明能抑制HIV-1，但与其他病毒性疾病不同，它不能治愈感染。在美国食品和药物管理局（FDA）批准的各种抗逆转录病毒药物中，核苷/核苷酸逆转录酶抑制剂（NRTIs）在限制HIV-1感染方面最有效。本文就NRTIs的作用机制和代谢作一综述。检索PubMed（1982-2016）以获取有关NRTI药理学的相关文章。介绍了目前防治HIV-1的经典NRTIs药理学。最后，提出了各种新的策略来提高nrti的疗效，这将提高当前HIV-1预防/治疗方案的治疗效率。nrti的使用将继续是成功治疗和预防HIV-1的关键。
Human immunodeficiency virus type-1 (HIV-1) infection leads to acquired immunodeficiency syndrome (AIDS), a severe viral infection that has claimed approximately 658,507 lives in the US between the years 2010–2014. Antiretroviral (ARV) therapy has proven to inhibit HIV-1, but unlike other viral illness, not cure the infection. Among various Food and Drug Administration (FDA)-approved ARVs, nucleoside/nucleotide reverse transcriptase inhibitors (NRTIs) are most effective in limiting HIV-1 infection. This review focuses on NRTIs mechanism of action and metabolism. A search of PubMed (1982–2016) was performed to capture relevant articles regarding NRTI pharmacology. The current classical NRTIs pharmacology for HIV-1 prevention and treatment are presented. Finally, various novel strategies are proposed to improve the efficacy of NRTIs, which will increase therapeutic efficiency of present-day HIV-1 prevention/treatment regimen. Use of NRTIs will continue to be critical for successful treatment and prevention of HIV-1.