Experience is required for the maintenance and refinement of FM sweep selectivity in the developing auditory cortex.
Experience is required for the maintenance and refinement of FM sweep selectivity in the developing auditory cortex.
复制标题
在发育中的听觉皮层中维持和完善调频扫描选择性需要经验。
DOI：
10.1073/pnas.0709504105
复制
发表时间：
2008
影响因子：
11.1
通讯作者：
Fuzessery,ZoltanM
中科院分区：
文献类型：
--
作者：
Razak,KhaleelA;Richardson,MarlinD;Fuzessery,ZoltanM
调频（FM）扫描是发声的常见组成部分，包括人类语音。发育经验如何塑造神经元对这些重要信号的选择性尚不清楚。在这里，我们表明，改变的发展经验与FM扫描回声定位苍白蝙蝠导致边带抑制或毫秒延迟的抑制性输入的时间，这两者都导致减少率和方向选择性的听觉皮层的损失。FM速率选择性以不依赖经验的方式发展，但需要后续维护的经验。方向选择取决于开发和维护的经验。速率和方向选择性受发育过程中不同时间段的经验影响。抑制改变可能是发声选择性的经验依赖性可塑性的一般机制。
Frequency modulated (FM) sweeps are common components of vocalizations, including human speech. How developmental experience shapes neuronal selectivity for these important signals is not well understood. Here, we show that altered developmental experience with FM sweeps used in echolocation by the pallid bat leads to either a loss of sideband inhibition or millisecond delays in the timing of inhibitory inputs, both of which lead to a reduction in rate and direction selectivity in auditory cortex. FM rate selectivity develops in an experience-independent manner, but requires experience for subsequent maintenance. Direction selectivity depends on experience for both development and maintenance. Rate and direction selectivity are affected by experience over different time periods during development. Altered inhibition may be a general mechanism of experience-dependent plasticity of selectivity for vocalizations.