Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma
Comparative efficacy of oral dexamethasone versus oral prednisone in acute pediatric asthma
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DOI：
10.1067/mpd.2001.115021
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发表时间：
2001-07-01
影响因子：
5.1
通讯作者：
Poirier, MP
中科院分区：
文献类型：
--
作者：
Qureshi, F;Zaritsky, A;Poirier, MP
Objective: The objective was to determine whether 2 days of oral dexamethasone (DEX) is more effective than 5 days of oral prednisone/prednisolone (PRED) in improving symptoms and preventing relapse in children with acute asthma.Study design: This was a prospective randomized trial of children (2 to 18 Sears old) who presented to the emergency department with acute asthma. PRED 2 mg/kg, maximum 60 mg (odd days) or DEX 0.6 mg/kg, maximum 16 mg (even days) was used. At discharge children in the PRED group were prescribed 4 daily doses (1 mg/kg/d, maximum 60 mg); children in the DEX group received a prepackaged dose (0.6 mg/kg, maximum 16 mg) to take the next day. The primary outcome was relapse within 10 days.Results: When DEX was compared with PRED, relapse rates (7.4% of 272 vs 6.9% of 261), hospitalization rates from the emergency department (11% vs 12%) or after relapse (20% vs 17%), and symptom persistence at 10 days (22% vs 21%) were similar. In the PRED group more children were excluded for vomiting in the emergency department (3% vs 0.3%; P =.008), more parents were noncompliant (4% vs 0.4%; P =.004), and more children missed greater than or equal to2 days of school (19.5% vs 13.2%; P =.05).Conclusion: In children with acute asthma, 2 doses of dexamethasone provide similar efficacy with improved compliance and fewer side effects than 5 doses of prednisone.
