Mechanosensitive Ion Channels: TRPV4 and P2X7 in Disseminating Cancer Cells.
Mechanosensitive Ion Channels: TRPV4 and P2X7 in Disseminating Cancer Cells.
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DOI：
10.1097/ppo.0000000000000312
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
King MR
中科院分区：
文献类型：
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作者：
Hope JM;Greenlee JD;King MR
癌症转移是美国第二大死亡原因。尽管具有发病率，但转移是一个低效的过程，很少有细胞能够存活。然而，癌细胞通常可以通过细胞对微环境线索的反应（例如通过机械转导）克服这些转移障碍。本综述重点关注机械敏感离子通道 TRPV4 和 P2X7 及其在转移中的作用，因为这两种通道已被证明对肿瘤细胞传播具有显着影响。激活后，这些通道有助于形成肿瘤新血管系统，促进跨内皮迁移并增加细胞运动。相反，它们也与依赖于激活水平的癌细胞死亡形式有关，这意味着机械敏感离子通道的复杂功能。了解 TRPV4、P2X7 和其他机械敏感离子通道在这些过程中的作用可能会揭示新的可能药物靶标，这些药物靶标可以改变通道功能以降低肿瘤的转移潜力。
Cancer metastasis is the second leading cause of death in the United States. Despite its morbidity, metastasis is an inefficient process that few cells can survive. However, cancer cells can often overcome these metastatic barriers via cellular responses to microenvironmental cues, such as through mechanotransduction. This review focuses on the mechanosensitive ion channels TRPV4 and P2X7, and their roles in metastasis, as both channels have been shown to have significant effects on tumor cell dissemination. Upon activation, these channels help form tumor neovasculature, promote transendothelial migration, and increase cell motility. Conversely, they have also been linked to forms of cancer cell death dependent upon levels of activation, implying the complex functionality of mechanosensitive ion channels. Understanding the roles of TRPV4, P2X7 and other mechanosensitive ion channels in these processes may reveal new possible drug targets that modify channel function to reduce a tumor’s metastatic potential.