Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells
Overexpression of cyclin B1 antagonizes chemotherapeutic-induced apoptosis through PTEN/Akt pathway in human esophageal squamous cell carcinoma cells
复制标题
细胞周期蛋白B1过表达通过PTEN/Akt通路拮抗人食管鳞癌细胞化疗诱导的细胞凋亡
DOI：
10.4161/cbt.22627
复制
发表时间：
2013-01-01
影响因子：
3.6
通讯作者：
Zhan, Qimin
中科院分区：
文献类型：
--
作者：
Ou, Yunwei;Ma, Liying;Zhan, Qimin
细胞周期蛋白B1在人食管鳞状细胞癌（ESCC）临床治疗敏感性中的作用仍有待明确。在本研究中，我们发现cyclin B1表达升高可减弱顺铂或紫杉醇诱导的ESCC细胞凋亡，而cyclin B1表达下调可增强顺铂或紫杉醇对ESCC细胞的敏感性。Cyclin B1介导的细胞凋亡可能依赖于bcl -2依赖性线粒体调控的内在死亡途径，而Cyclin B1对化疗药物诱导的细胞凋亡的拮抗作用是通过PTEN/Akt途径实现的。因此，细胞周期蛋白B1可能是开发特异性和有效治疗ESCC方法的治疗靶点。
The role of cyclin B1 in the clinical therapeutic sensitivity of human esophageal squamous cell carcinoma (ESCC) remains to be defined. In this study, we found that elevated cyclin B1 expression attenuated the apoptosis induced by cisplatin or paclitaxel, while knockdown of cyclin B1 enhanced cisplatin or paclitaxel sensitivity in ESCC cells. Cyclin B1-mediated apoptosis may rely on the Bcl-2-dependent mitochondria-regulated intrinsic death pathway, and the antagonizing effect of cyclin B1 on chemotherapeutic agent-induced apoptosis was through PTEN/Akt pathway. Therefore, cyclin B1 might be a therapeutic target for the development of specific and efficient approaches in the treatment of ESCC.