Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid
Apatite-forming ability of carboxyl group-containing polymer gels in a simulated body fluid
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DOI：
10.1016/s0142-9612(03)00050-4
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发表时间：
2003-06-01
期刊：
影响因子：
14
通讯作者：
Nakamura, T
中科院分区：
文献类型：
--
作者：
Kawashita, M;Nakao, M;Nakamura, T
将羧甲基化甲壳素、结冷胶和可得兰凝胶浸泡在离子浓度几乎等于人血浆的模拟体液（SBF）中。一些凝胶已经浸泡在饱和Ca（OH）（2）溶液中，而另一些则没有。羧甲基化甲壳质和结冷胶凝胶具有羧基，而可得然胶凝胶具有羟基。当没有经过Ca（OH）（2）处理时，没有凝胶在SBF中在其表面上形成磷灰石，而羧甲基甲壳素和结冷胶凝胶在经过Ca（OH）（2）处理时在其表面上形成磷灰石。即使在Ca（OH）（2）处理后，可得兰凝胶也不形成磷灰石存款。羧甲基甲壳素和结冷胶凝胶上磷灰石的形成归因于其羧基对磷灰石成核的催化作用，以及释放的Ca 2+离子对磷灰石成核的加速作用。这一结果为获得磷灰石-有机聚合物纤维复合材料提供了指导原则。这种复合材料预期具有与天然骨类似的结构。(C)2003爱思唯尔科技有限公司。保留所有权利。
Carboxymethylated chitin, gellan gum, and curdlan gels were soaked in a simulated body fluid (SBF) having ion concentrations nearly equal to those of human blood plasma. Some of the gels had been soaked in a saturated Ca(OH)(2) solution, while others had not. The carboxymethylated chitin and gellan gum gels have carboxyl groups, while the curdlan gel has hydroxyl groups. None of the gels formed apatite on their surfaces in the SBF when they had not been subjected to the Ca(OH)(2) treatment, whereas the carboxymethylated chitin and gellan gum gels formed apatite on their surfaces when they had been subjected to the Ca(OH)(2) treatment. The curdlan gel did not form an apatite deposit even after the Ca(OH)(2) treatment. Apatite formation on the carboxymethylated chitin and gellan gum gels was attributed to the catalytic effect of their carboxyl groups for apatite nucleation, and acceleration of apatite nucleation from released Ca2+ ions. This result provides a guiding principle for obtaining apatite-organic polymer fiber composites. This composite is expected to have an analogous structure to that of natural bone. (C) 2003 Elsevier Science Ltd. All rights reserved.