AMPHIPHILIC SECONDARY STRUCTURE - DESIGN OF PEPTIDE-HORMONES
AMPHIPHILIC SECONDARY STRUCTURE - DESIGN OF PEPTIDE-HORMONES
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DOI：
10.1126/science.6322295
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发表时间：
1984-01-01
期刊：
影响因子：
56.9
通讯作者：
KEZDY, FJ
中科院分区：
文献类型：
--
作者：
KAISER, ET;KEZDY, FJ
肽合成可用于阐明二级结构在激素、抗原和毒素的特异性中的作用。具有这些活性的中等大小的肽在膜存在下呈现两亲性二级结构。当设计模型以优化二级结构的两亲性时，可以观察到与合成肽的相互作用比与天然存在的类似物的相互作用更强。
Peptide synthesis can be used for elucidating the roles of secondary structures in the specificity of hormones, antigens, and toxins. Intermediate sized peptides with these activities assume amphiphilic secondary structures in the presence of membranes. When models are designed to optimize the amphiphilicity of the secondary structure, stronger interactions can be observed with the synthetic peptides than with the naturally occurring analogs.