Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial
Prevention of antipsychotic-induced weight gain with early behavioural intervention in first-episode psychosis: 2-year results of a randomized controlled trial
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DOI：
10.1016/j.schres.2009.10.012
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发表时间：
2010-01-01
影响因子：
4.5
通讯作者：
Crespo-Facorro, Benedicto
中科院分区：
文献类型：
--
作者：
Alvarez-Jimenez, Mario;Martinez-Garcia, Obdulia;Crespo-Facorro, Benedicto
虽然体重管理干预措施在减轻抗精神病药物引起的体重方面是有效的，但没有关于其长期有效性的证据。本研究旨在调查早期行为干预（EBI）的2年效果，该干预旨在预防首次发作精神病（FEP）患者抗精神病药物诱导的体重增加。61例FEP患者随机接受EBI或常规治疗。意向治疗和随访病例分析显示，EBI组患者在干预完成时（3个月随访）体重增加显著低于常规治疗组，治疗效果维持3个月以上。到12个月时，组间差异不再显著。体重管理干预可能需要提供更长的时间，以保持预防效果。或者，可能需要在干预完成后定期进行加强治疗。(C)2009 Elsevier B.V.保留所有权利。
While weight-management interventions are effective in attenuating antipsychotic-induced weight, there is no available evidence on their long-term effectiveness. This study sought to investigate the 2-year effects of an early behavioural intervention (EBI) designed to prevent antipsychotic-induced weight gain in first-episode psychosis (FEP) patients. Sixty-one FEP patients were randomized to receive either EBI or treatment-as-usual. Intention-to-treat and observed-cases analysis showed that patients in the EBI group gained significantly less weight than those allocated to routine care at intervention completion (3-month follow-up) with treatment effects maintained over 3 months. Differences between groups were no longer significant by 12 months. Weight-management interventions may need to be offered for longer periods to maintain preventative effects. Alternatively, booster sessions may need to be regularly delivered after intervention completion. (C) 2009 Elsevier B.V. All rights reserved.