Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate
Thermal decomposition of a generation 4.5 PAMAM dendrimer platinum drug conjugate
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DOI：
10.1007/s10973-005-7333-0
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发表时间：
2006-01-01
影响因子：
4.4
通讯作者：
Rakesh, Leela
中科院分区：
文献类型：
--
作者：
Howell, B. A.;Fan, D.;Rakesh, Leela
一种基于聚（酰胺 - 胺）[PAMAM]树枝状大分子（第4.5代，羧酸盐表面）的纳米级多价铂类药物已被合成，并使用多种光谱、色谱和热分析方法进行了全面表征。用含有过量二水（顺 - 1,2 - 二氨基环己烷）铂（II）的水溶液处理树枝状大分子，会产生一种在树枝状大分子表面含有约四十个（二氨基环己烷）铂（II）部分的共轭物。这种物质会平稳地经历两阶段热分解，产生反映药物中铂负载量的残留氧化铂。
A nanoscale multivalent platinum drug based on a poly(amidoamine) [PAMAM] dendrimer (generation 4.5, carboxylate surface) has been synthesized and fully characterized using a variety of spectroscopic, chromatographic and thermal methods. Treatment of the dendrimer with an aqueous solution containing an excess diaquo(cis-1,2-diaminocyclohexane)platinum(II) produces a conjugate containing approximately forty (diaminocyclohexane)platinum(II) moieties at the surface of the dendrimer. This material undergoes smooth two-stage thermal decomposition to provide residual platinum oxide reflecting the platinum loading in the drug.