Henoch-Schonlein Purpura in adults: Outcome and prognostic factors
Henoch-Schonlein Purpura in adults: Outcome and prognostic factors
复制标题
DOI：
10.1097/01.asn.0000013883.99976.22
复制
发表时间：
2002-05-01
影响因子：
13.6
通讯作者：
Nochy, D
中科院分区：
文献类型：
--
作者：
Pillebout, E;Thervet, E;Nochy, D
过敏性紫癜性肾炎（HSPN）在儿童中已被广泛研究，但其在成人中的自然史却鲜为人知。对250名患有HSP的成年人进行了回顾性分析，中位随访期为14.8年。所有患者的活检结果均与HSP（主要伊加系膜沉积）一致，并伴有紫癜、肠绞痛和/或腹痛。在临床表现中，96%的患者出现可触及的紫癜，61%的患者报告关节炎，48%的患者报告胃肠道受累。32%的患者显示肾功能不全（肌酐清除率[CrCl]
Henoch-Schonlein Purpura nephritis (HSPN) has been extensively studied in children but, its natural history in adults is much less known. A cohort of 250 adults suffering HSP was retrospectively analyzed for a median follow-up period of 14.8 yr. All patients had biopsies consistent with HSP (predominant IgA mesangial deposits) associated with purpura, bowel angina, and/or abdominal pain. At presentation, palpable purpura was present in 96% of patients, and arthritis was reported in 61%, and gastrointestinal involvement in 48%. Thirty-two percent of the patients showed renal insufficiency (Creatinine clearance [CrCl]