Novel Dopamine D2 Receptor Signaling through Proteins Interacting with the Third Cytoplasmic Loop
Novel Dopamine D2 Receptor Signaling through Proteins Interacting with the Third Cytoplasmic Loop
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DOI：
10.1007/s12035-011-8227-8
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发表时间：
2012-02-01
影响因子：
5.1
通讯作者：
Shioda, Norifumi
中科院分区：
文献类型：
--
作者：
Fukunaga, Kohji;Shioda, Norifumi
多巴胺D2样受体（包括D2、D3和D4受体）的多种活性由与第三胞质环相互作用并调节受体信号传导、受体运输和细胞凋亡的蛋白质介导。这些相互作用蛋白包括钙调蛋白、N-甲基-D-天冬氨酸受体2B亚基、钙/钙调蛋白依赖性蛋白激酶II、前列腺凋亡反应-4和β-抑制蛋白，它们通过D2受体调节受体信号传导和药理作用。编码D2受体的基因产生两种亚型，称为多巴胺D2受体长亚型（D2 L）和多巴胺D2受体短亚型;后者在第三胞质环内缺乏D2 L受体的29个氨基酸。在这篇综述中，我们首先集中在异源寡聚体D1/D2和D2/腺苷A2 A受体的新功能。接下来，我们将讨论通过与D2受体第三胞质环相互作用的蛋白质的新信号传导，并定义一种新的结合蛋白，心脏型脂肪酸结合蛋白，其与D2 L第三胞质环相互作用的功能。
The diverse activities of dopamine D2-like receptors, including D2, D3, and D4 receptors, are mediated by proteins that interact with the third cytoplasmic loop and regulate receptor signaling, receptor trafficking, and apoptosis. Such interacting proteins include calmodulin, the N-methyl-D-aspartate receptor 2B subunit, calcium/calmodulin-dependent protein kinase II, prostate apoptosis response-4, and beta-arrestins, which regulate receptor signaling and the pharmacological action through D2 receptor. The gene encoding the D2 receptor gives rise to two isoforms, termed the dopamine D2 receptor long isoform (D2L) and the dopamine D2 receptor short isoform; the latter lacks 29 amino acids of the D2L receptor within the third cytoplasmic loop. In this review, we first focus on novel functions of the hetero-oligomeric D1/D2 and D2/adenosine A2A receptors. We next discuss novel signaling through proteins interacting with the D2 receptor third cytoplasmic loop and define the function of a novel binding protein, heart-type fatty acid binding protein, which interacts with the D2L third cytoplasmic loop.