Grand Challenges in Comparative Tooth Biology
Grand Challenges in Comparative Tooth Biology
复制标题
比较牙齿生物学的巨大挑战
DOI：
10.1093/icb/icaa038
复制
发表时间：
2020
影响因子：
2.6
通讯作者：
Fraser, Gareth J
中科院分区：
文献类型：
--
作者：
Hulsey, C Darrin;Cohen, Karly E;Johanson, Zerina;Karagic, Nidal;Meyer, Axel;Miller, Craig T;Sadier, Alexa;Summers, Adam P;Fraser, Gareth J
牙齿是一个集发育基因组学、功能形态学和进化为一体的模型系统。我们正处于能够解决比较牙齿生物学中许多开放问题的尖端，我们概述了这些新的易于处理和令人兴奋的研究方向。前所未有的技术进步和方法方法使我们能够研究脊椎动物的发育机制，并发现保守的和令人兴奋的新多样化机制。此外，对软组织多样性、替代牙和牙齿非营养功能的研究为牙齿多样性提供了新的见解。最后，我们强调了几个新兴的生物模型组，它们处于提高我们对牙齿多样化机制的认识的前沿。
Teeth are a model system for integrating developmental genomics, functional morphology, and evolution. We are at the cusp of being able to address many open issues in comparative tooth biology and we outline several of these newly tractable and exciting research directions. Like never before, technological advances and methodological approaches are allowing us to investigate the developmental machinery of vertebrates and discover both conserved and excitingly novel mechanisms of diversification. Additionally, studies of the great diversity of soft tissues, replacement teeth, and non-trophic functions of teeth are providing new insights into dental diversity. Finally, we highlight several emerging model groups of organisms that are at the forefront of increasing our appreciation of the mechanisms underlying tooth diversification.