CONFORMATIONAL-CHANGES OF TRANSFER-RNA - ROLE OF MAGNESIUM(II)
CONFORMATIONAL-CHANGES OF TRANSFER-RNA - ROLE OF MAGNESIUM(II)
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DOI：
10.1021/bi00646a025
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发表时间：
1976-01-01
期刊：
影响因子：
2.9
通讯作者：
CROTHERS, DM
中科院分区：
文献类型：
--
作者：
STEIN, A;CROTHERS, DM
Magnesium ions added to tRNAIMRTi selec-tively stabilize the dihydrouridine helix-tertiary structural region. Low Mg2+ levels have little direct effect on the re-maining three cloverleaf helices, but these are prevented from melting independently when their intrinsic Tm is sur-passed by the Tm of the tertiary structure. At high Mg2+ concentration the thermal unfolding of tRNA, Meli is ap-proximately a two-state, concerted transition from the globular native structure to the random coil, in contrast to the sequential unfolding observed without Mg2+. We interpret
