Assessing the Preliminary Efficacy of a Nonrandomized, Clinic-Based HIV Risk Reduction Pilot Intervention for PrEP-Initiated, Alcohol- and Other Drug-Using Women of Color in Miami, FL.
Assessing the Preliminary Efficacy of a Nonrandomized, Clinic-Based HIV Risk Reduction Pilot Intervention for PrEP-Initiated, Alcohol- and Other Drug-Using Women of Color in Miami, FL.
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DOI：
10.1007/s40615-022-01482-5
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发表时间：
2023-12
影响因子：
3.9
通讯作者：
Devieux, Jessy G
中科院分区：
文献类型：
--
作者：
Ichite, Amanda;Jean-Gilles, Michele;Rosenberg, Rhonda;Abbamonte, John;Devieux, Jessy G
在本文中，我们评估了一个准实验性的，基于临床的性风险降低试点干预暴露前预防（PrEP）启动，酒精和其他药物使用的有色人种妇女的初步疗效和可接受性，并探讨了他们自我报告的障碍，和促进者，PrEP使用。使用混合方法设计，分析纳入干预前和干预后的研究评估数据，从38名妇女和半结构化的过程中使用的子样本的25个评价。为期8周的干预包括4次一对一的面对面教育课程，过程评估以及在基线和3个月和6个月进行的研究评估。干预后，未观察到性风险评分的统计学显著变化;然而，我们发现酒精使用显著减少（Z =-3.02，p = .003，η2 = .41）。过程评估数据显示，人际关系是PrEP启动的关键动力，也是PrEP使用的主要障碍;这些关系很少促进依从性。总的来说，妇女发现干预是可以接受的，并报告了广泛的参与利益，最显着的是其治疗效益。这项研究的结果提供了初步的证据，证明了与有色人种女性进行谈话的PrEP干预可能会改善与性冒险相关的风险行为、知识和态度。此外，研究结果表明，增加高危妇女PrEP吸收和坚持的干预措施可能会受益于支持她们准确估计艾滋病毒风险并增加她们的社会支持感。
In this paper, we assessed the preliminary efficacy and acceptability of a quasi-experimental, clinic-based sexual risk reduction pilot intervention for pre-exposure prophylaxis (PrEP)-initiated, alcohol- and other drug-using women of color and explored their self-reported barriers to, and facilitators of, PrEP use. Using a mixed methods design, analyses incorporated pre- and post-intervention study assessment data from 38 women and semi-structured process evaluations using a subsample of 25. The intervention administered over an 8-week period consisted of 4 one-on-one in person educational sessions, a process evaluation, and study assessments conducted at baseline and 3 and 6 months. Post intervention, statistically significant changes in sexual risk scores were not observed; however, we found significant decreases in alcohol use (Z = − 3.02, p = .003, η2 = .41). Process evaluation data revealed interpersonal relationships as a key motivator for PrEP initiation as well as a prominent barrier to PrEP use; these relationships rarely facilitated adherence. Overall, women found the intervention to be acceptable and reported a wide range of benefits of participation—most notably its therapeutic benefits. Findings from this study provide preliminary evidence of the potential for the Talking PrEP with Women of Color intervention to improve risky behaviors, knowledge, and attitudes related to sexual risk taking. Furthermore, findings suggest that interventions to increase PrEP uptake and adherence in at-risk women may benefit from supporting them in accurately estimating their risk for HIV and increasing their sense of social support.
影响因子：
1.7
作者：
Sewell WC;Blankenship SA
通讯作者：
Blankenship SA
影响因子：
2.7
作者：
Collins PY;von Unger H;Putnins S;Crawford N;Dutt R;Hoffer M
通讯作者：
Hoffer M